Synthesis and characterization of water-soluble, heteronuclear ruthenium(III)/ferrocene complexes and their interactions with biomolecules

Abstract

The reaction of Na[RuCl4(SO(CH3)2)2], 1, with one equivalent of FcCONHCH2C6H4N (Fc=FeC10H9), L1, FcCOOCH2CH2C3H3N2, L2, FcCOOC6H4N, L3, afforded the dinuclear species, Na[FcCONHCH2C6H4N[RuCl4(SO(CH3)2)]], RuL1, Na[FcCOOCH2CH2C3H3N2[RuCl4(SO(CH3)2)]], RuL2, Na[FcCOOC6H4N(RuCl4(SO(CH3)2))], RuL3, respectively, yielding, in each case, a ferrocene moiety bridged to a ruthenium center. The complexes were characterized by NMR, IR, and XRD (X-ray diffraction). The sulfoxide ligands are bonded to the metal through the sulfur atom. The complexes were evaluated for their biological activity with pBluescript DNA plasmid, and the protein BSA (bovine serum albumin). These reactions were monitored by XAS (X-ray absorption spectroscopy), EXAFS (extended X-ray Absorption Fine Structure), NMR, UV/visible, emission spectroscopy, and gel electrophoresis. Donor atoms from the biomolecules substitute for the chloride ligands in the parent complexes.

Ferrocene-Appended Iridium(III) Complexes: Configuration Regulation, Anticancer Application, and Mechanism Research

“…Different from traditional single metal complexes, multinuclear or heteronuclear metal complexes have confirmed potential advantages in the field of anticancer, including better biological activity and different anticancer mechanisms . Given the great potential of ferrocene and Ir III complexes in the field of anticancer, in this paper, ferrocene-modified phenylpyridine was prepared by the classical Wittig reaction, further reacted with the dimer of Ir III , and constructed the iridium–iron heteronuclear anticancer complexes (complexes 1 – 4 , Figure ).…”

Newly Synthesized Heteronuclear Ruthenium(II)/Ferrocene Complexes Suppress the Growth of Mammary Carcinoma in 4T1-Treated BALB/c Mice by Promoting Activation of Antitumor Immunity

“…13,17 Ever since Woodward reported Friedel−Crafts acylation of ferrocene, 18 various ferrocenyl derivatives have been synthesized using classical organic synthesis. 19,20 Ferrocenyl derivatives have appeared as attractive candidates for potential treatment of not only human cancers 21 but also infective diseases such as malaria, 22 fungal and bacterial infections, 23 and human immunodeficiency virus (HIV). 24 The biological attractiveness of ferrocene-based metallo complexes should be sought in their stability in aqueous solutions and air and then, in their ability to enter cells, in their ease of chemical modification and their redox activity.…”

“…Many chemists have shown particular interest in ferrocenyl derivatives that contain one or more heteroatoms, such as monodentate ligands that form coordinative bonds with transition metals or polydentate ligands that form several bonds with metal atoms (chelates). , Ever since Woodward reported Friedel–Crafts acylation of ferrocene, various ferrocenyl derivatives have been synthesized using classical organic synthesis. , Ferrocenyl derivatives have appeared as attractive candidates for potential treatment of not only human cancers but also infective diseases such as malaria, fungal and bacterial infections, and human immunodeficiency virus (HIV) . The biological attractiveness of ferrocene-based metallo complexes should be sought in their stability in aqueous solutions and air and then, in their ability to enter cells, in their ease of chemical modification and their redox activity. − Ferrocene itself is not cytotoxic, but the ferrocenium ionits singly charged cationis cytotoxic .…”

Synthesis and X-ray Structural Analysis of the Ruthenium(III) Complex Na[trans-RuCl4(DMSO) (PyrDiaz)], the Diazene Derivative of Antitumor NAMI-Pyr

“…The Ru-N and Ru-S bond distances of 2.109(6) and 2.2924(17) Å, respectively, are very similar to those found in the related structures containing trans-RuNCl 4 S donor set. [33][34][35]37 Three of the chlorido ligands are terminal while Cl4 forms a bridge between the ruthenium and sodium atoms. The DMSO ligand also forms a bridge between a ruthenium centre (through its sulphur atom) and a sodium (through its oxygen) thus forming a five membered RuClNaOS ring in the crystal structure.…”

“…A similar coordination environment around sodium ion has been found in related tetrachloridoruthenium(III) complexes. [33][34][35][36] The crystal structure of 3 is further stabilized by three intramolecular hydrogen bonds of the type N-H···O and N-H···F (Table 3).…”