Synthesis and Characterization of Water-Soluble Dendronized Chitosan Using Newkome-Type Dendrons

Abstract

With increasing emphasis on environmental care and use of renewable resources, simple and effective dendronization processes were performed to obtain chitosan derivatives. We present different alternatives for the modification of chitosan: dendronization with a biocompatible dendron; a quaternization process with an ammonium salt, which confers a permanent positive charge to the polymer; and a combination of methodologies allowing amphiphilic polymers. This process confers unique multivalent properties to the native chitosan, and further modifications reach multivalent water-soluble polymers. Hence, the most important highlight of this work is the use of renewable natural polymers and the different methodologies applied to nontoxic solvents with low temperatures. The process described in this paper represents a sustainable alternative for obtaining a functionalized material with properties suitable for application in different areas, such as biomedicine or environmental remediation.

Preparation of Elastic and Antibacterial Chitosan–Citric Membranes with High Oxygen Barrier Ability by in Situ Cross-Linking

“…Citric acid can be successfully attached to the chitosan backbone to fabricate the model polymer, according to the reference method. 42 EDC (4.0 g) dissolved in 50 mL of solution containing deionized water and ethanol (1:1, v/v) was slowly dropped to the deionized water solution (50 mL) containing chitosan (2.5 g) and citric acid (4.0 g). The reaction mixture was stirred with pH value maintained at 5.0 at room temperature.…”

Synthesis and characterization of linear dendritic homo and copolymers acrylated behera amine

“…These cleavable end groups were used to modify chitosan in order to impart water solubility after the hydrolysis of tertiary butoxide groups. [9] This dendron was also utilized in synthesis of dendritic perylenes that are suitable for the chemical functionalization of inorganic nanoparticles and dendronized polycationic perylenetetracarboxylic acid diimides. [10,11] Newkome-type dendronized norbornene macromonomers were synthesized and polymerized by ring-opening metathesis polymerization to obtain biocompatible polymers.…”

Experimental study and calculation of the electron transfer coefficients on the dissolution behavior of chitosan in organic acids

“…[12] Experimental analysis The solubility of CH in aqueous solutions of organic acids for the formation of filmswas evaluated as follows: 1% low molecular weight CH (Sigma-Aldrich) was added in 20mL of 0.1 M solution of organic acids in duplicate ( Table 3). The solution was dissolve at 25°C, with magnetic stirring at 660 rpm for 15 minutes, and the final solution was filtered [14][15] . The CH films were made by the plate casting method [16] .…”