Synthesis and characterization of ZIF-8 nanoparticles for controlled release of 6-mercaptopurine drug

Fluoride removal from living entities is the foremost task as it is a non-biodegradable and harmful pollutant mostly found in groundwater. Nowadays, the application of nanoparticles as an adsorbent of fluoride is becoming an intense research due to its high surface area. In the present study, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles adsorption behavior and its efficiency in fluoride removal from an aqueous phase were studied. Various structures, sizes and morphologies of nanoparticles were investigated by Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscope, transmission electron microscopy, Raman spectroscopy and zeta seizer. By varying process parameters such as contact time, adsorbent dosage, stirring rate, temperature, and pH, batch adsorption was carried out. The optimum conditions for fluoride removal by ZIF-8 nanoparticles were found as contact time 15 min, adsorbent dosage 0.06 g/L, agitation rate 400 rpm, temperature 20 °C, pH 8. Pseudo-second order in kinetic study showcases that the regression coefficient was found to be 0.99. The experimental data of Langmuir isotherm model of adsorption system reveal the adsorption capacity of 90 mg/g which has better adsorption capacity than other adsorbents. The isothermal multistage adsorption was also studied to understand the mechanism of adsorption of ZIF-8 nanoparticles for fluoride removal. The result in the present work gives a promising adsorbent for the fluoride removal.

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“…The zeta seizer shows particle size range of ZIF-8 nanoparticles from 200-300 nm as same as that shown by TEM in Fig. 6 (Kaur et al 2017).…”

Section: Characterization Of Materialssupporting

confidence: 71%

Zeolitic imidazolate framework-8 nanoparticle: a promising adsorbent for effective fluoride removal from aqueous solution

et al. 2019

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“…For the common drugs without strong interactions with MOFs, it was highly demanded to realize an efficient strategy for solving their low drug loading content and burst release behavior in MOF carriers. Among MOFs, zeolitic imidazolate framework‐8 (ZIF‐8) was the most attractive drug carrier because of its good biocompatibility and pH‐responsive degradability for controlled drug release . Consequently, it was of great significance to make the ZIF‐8 as a versatile drug carrier platform with successful drug encapsulation for various common drugs.…”

Section: Introductionmentioning

confidence: 99%

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Zhang

Liu

et al. 2018

Adv Funct Materials

203

147

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Zeolitic imidazolate framework-8 (ZIF-8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF-8 is essential for high drug loadings through in situ construction of MOFs. However, only limited drugs with unique functional groups (COOH, SO 3 H, et al.) can interact with ZIF-8 and be encapsulated satisfactorily so far. Drugs without these functional groups are difficult to be loaded due to the lack of strong interaction. Herein a versatile prodrug strategy is proposed to solve the problems encountered by MOFs. Cytarabine (Ara) is chosen as a model drug since it cannot be loaded in ZIF-8 satisfactorily by itself. New indocyanine green (IR820) is utilized to bond with Ara for the formation of prodrug (Ara-IR820) and endows the prodrug with fluorescence imagingguided chemo-photothermal therapy, in which sulfonic groups strengthen the interaction between prodrug and ZIF-8. This prodrug loaded ZIF-8 is further functionalized with hyaluronic acid (HA) to result in active-targeting HA/ Ara-IR820@ZIF-8 nanoparticles. The in vitro and in vivo results demonstrate its excellent visual cancer therapy with tumor-targeted and pH-responsive release behavior. This design offers a new concept to solve the drug loading problem of MOFs, exhibiting a flexible strategy to expand the biomedical applications of MOFs.

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“…ZIFs possess the unique properties of high crystallinity, large surface area, exceptional chemical and functional tunability. As a result, ZIFs have gained considerable attention for their potential application in gas storage 2 , CO 2 capture 3,4 , separation 5,6 , sensing 7 , catalysis 8 , drug delivery 9,10 and water treatment 11,12 . Zeolitic imidazolate framework-8 (ZIF-8), with sodalite (SOD) topology constructed from Zn and Hmim, is one of the most investigated ZIF materials 13–15 .…”

Section: Introductionmentioning

confidence: 99%

Influence of the 2-methylimidazole/zinc nitrate hexahydrate molar ratio on the synthesis of zeolitic imidazolate framework-8 crystals at room temperature

Zhang

Jia

et al. 2018

Sci Rep

150

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The effect of the 2-methylimidazole (Hmim)/zinc nitrate hexahydrate (Zn) molar ratio on the physicochemical characteristics of the zeolitic imidazolate framework-8 (ZIF-8) was investigated. ZIF-8 crystals were synthesized by mixing Hmim with Zn at room temperature without any additives in methanol solution. It was found that Hmim/Zn molar ratio had significant influence on the crystallinity, yield, particle size and porosity of ZIF-8. The samples synthesized at low Hmim/Zn molar ratio showed a cubic shape, whereas at higher Hmim/Zn ratios truncated rhombic dodecahedron or rhombic dodecahedron morphologies were obtained. The particle size is decreased upon increasing the Hmim/Zn molar ratio. Besides, higher Hmim/Zn molar ratio in a certain range resulted in improving crystallinity, yield, surface area and micropore volume of ZIF-8. The ZIF-8 crystals produced at Hmim/Zn molar ratio of 8 exhibited the best characteristics. The present work provides new insights in relation to the role of Hmim/Zn molar ratio on the synthesis process of ZIF-8.

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Synthesis and characterization of ZIF-8 nanoparticles for controlled release of 6-mercaptopurine drug

Cited by 305 publications

References 33 publications

Zeolitic imidazolate framework-8 nanoparticle: a promising adsorbent for effective fluoride removal from aqueous solution

Zeolitic imidazolate framework-8 nanoparticle: a promising adsorbent for effective fluoride removal from aqueous solution

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Influence of the 2-methylimidazole/zinc nitrate hexahydrate molar ratio on the synthesis of zeolitic imidazolate framework-8 crystals at room temperature

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