Synthesis and characterization of zinc oxide nanocrystals and histologic evaluation of their biocompatibility by means of intraosseous implants

Abstract

ZnO nanocrystals were biocompatible, well tolerated and allowed new bone formation and bone remodelling.

Antibacterial Activity and Biocompability of Zinc Oxide and Graphite Particles as Endodontic Materials

“…5a). Similar fi ndings were informed by Augustine in wound skin healing model 53) and by Sousa in wound bone healing 54) . Also, the presence of infl ammatory cells and new vascular formation surrounding ZnO particles (Table 1) an unresolved infl ammation could be related to the dissolution of ZnO and hence ROS generation.…”

Assessment of the genotoxic potential of two zinc oxide sources (amorphous and nanoparticles) using the in vitro micronucleus test and the in vivo wing somatic mutation and recombination test

“…Here, the X-ray diffractogram and micro-Raman spectrum confirmed that the synthesis methodology employed produced pure, homogeneous and uncontaminated ZnO NPs, in hexagonal wurtzite (Wz) structures, with an average size of 20 nm. This methodology has been widely used and provides the best control over properties such as dimension, structure, purity and stability that are fundamental in biological assays (Song et al, 2010;Sousa et al, 2014). They suggested a 24 h exposure to be ample to determine genotoxic response; advised that the genotoxicity studies consider in parallel complete and reduced serum content in media and M A N U S C R I P T…”

“…ZnO NPs (average size of 20 nm) were synthesised by coprecipitation (Dantas et al, 2008a;Dantas et al, 2008b;Sousa et al, 2014). The reaction was complete after four hours and yielded a ZnO precipitate that was collected, centrifuged and washed five times, first with M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT diffractogram (XRD) was acquired using an XRD-6000 (Shimadzu) with monochromatic CuKa1 (λ = 1.54056 Å) radiation.…”

Biocompatibility of Doped Semiconductors Nanocrystals and Nanocomposites

“…Several types of nanocrystals have been synthesized in order to obtain an efficient nanomaterial. However, it is important to emphasize that nanocrystals must be biocompatible and specific [45]. Based on this and knowing that zinc oxide nanocrystals (ZnO) are biocompatible materials, according to the US Food and Drug Administration (FDA), in this chapter we investigated this nanocrystal.…”