Synthesis and characterization of β-cyclodextrin/carboxymethyl chitosan/hydroxyapatite fused with date seed extract nanocomposite scaffolds for regenerative bone tissue engineering

Jolly, Reshma; Furkan, Mohammad; Khan, Aijaz Ahmed; Ahmed, Shariq; Alam, Sharique; Farooqi, Mohd Ahmadullah; Khan, Rizwan Hasan; Shakir, Mohammad

doi:10.1039/d1ma00286d

Cited by 10 publications

(7 citation statements)

References 68 publications

(158 reference statements)

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“…The addition of nHA and β-CD-CHX increases the composite porous scaffold surface area and roughness. 37,38 This provides cell recognition sites that contribute to cell adhesion.…”

Section: 2mentioning

confidence: 99%

3D-Printed Drug-Loaded Composite Scaffolds to Promote Osteogenesis and Antibacterial Activity

Cheng

Liu

et al. 2022

ACS Appl. Polym. Mater.

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In order to produce a type of biocomposite, attractive and environmentally friendly biodegradable polymers are used in the field of materials science. Programable three-dimensional (3D) manufacturing technology conjointly provides a green platform to use polylactic acid (PLA) in bone tissue engineering. In this study, we printed PLA, nano-hydroxyapatite (nHA), and β-cyclodextrin/chlorhexidine clathrate (β-CD-CHX) using a 3D printing technique to prepare a porous composite scaffold (PLA/nHA/β-CD-CHX) with osteogenic and anti-infective properties. With scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy, we confirmed the successful printing of the PLA/nHA/β-CD-CHX and that the β-CD-CHX was uniformly distributed in the scaffold. The in vitro release behavior showed that the dual slow release of PLA/nHA/β-CD-CHX and β-CD-CHX could achieve sustained release of CHX. In addition, in vitro experiments demonstrated that the prepared PLA/nHA/β-CD-CHX exhibited outstanding cytocompatibility and induced osteogenesis. The anti-microbial test against Staphylococcus aureus and Escherichia coli demonstrated the outstanding antibacterial properties of the composite scaffold. These findings suggest that the 3D-printed PLA/nHA/β-CD-CHX scaffold has excellent potential for repairing regenerative jaw defects and fighting infections.

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“…The addition of nHA and β-CD-CHX increases the composite porous scaffold surface area and roughness. 37,38 This provides cell recognition sites that contribute to cell adhesion.…”

Section: 2mentioning

confidence: 99%

3D-Printed Drug-Loaded Composite Scaffolds to Promote Osteogenesis and Antibacterial Activity

Cheng

Liu

et al. 2022

ACS Appl. Polym. Mater.

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“…A biomimetic mineralization ability was observed for heterojunctions containing nanohydroxyapatite, carboxymethyl chitosan, and β ‐CD fused with date seed extract, which improved bone tissues regeneration. [ 192 ]…”

Section: Cyclodextrinsmentioning

confidence: 99%

“…A biomimetic mineralization ability was observed for heterojunctions containing nanohydroxyapatite, carboxymethyl chitosan, and 𝛽-CD fused with date seed extract, which improved bone tissues regeneration. [192] Biosensors are low-cost, highly sensitive devices that allow real-time disease detection and health monitoring by three components, i.e., i) a biological element, able to detect the analyte and generate a response signal, ii) a transducer, that converts the signal generated by the biological element into a detectable response, and iii) the detector, responsible for amplifying and processing the signals before displaying them on an electronic display. [193] CDs may act as biological elements and possess immense potential to contribute to the development of smart, cheap, and efficient devices for medical diagnostics.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Silva

Carvalho

Moraes

et al. 2022

Macro Chemistry & Physics

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Nature is a source of diverse materials, including polysaccharides, which have been used to improve the quality of life. Besides being abundant and renewable, polysaccharides possess many advantages, such as biodegradability and biocompatibility, which allow them to be applied in different fields. They can be used in the design and development of renewable materials, thus contributing to a more sustainable society. Because of their advantages and versatility, polysaccharides may be incorporated in many systems, particularly biomimetic ones, to create outstanding sustainable solutions to problems that still need to be solved. Hence, nature not only offers resources but an inspiration to overcome issues. In this sense, this work aims to present an overview of current relevant biomimetic systems based on polysaccharides. Chitosan, cellulose, xanthan gum, alginates, pullulan, hyaluronic acid, schizophyllan, and oligomeric cyclodextrins are covered. The application of these polysaccharides in the design of biosensors, systems for environmental remediation, structural materials, drug delivery systems, tissue engineering among others is described. Finally, the challenges that still need to be faced and opportunities of application of these materials for the development of bioinspired technologies in the next future are highlighted.

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“…2 Crystallite size and shape are important for the biomimetic application of materials in the body along with controlling degradation properties. 4 In addition to the biomedical application, HAp has been widely used in various fields such as wastewater treatment, 5 therapeutic ion delivery, 6 photocatalytic degradation, 7 etc. All these applications require special properties of materials which can enhance their applicability or efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…2 Crystallite size and shape are important for the biomimetic application of materials in the body along with controlling degradation properties. 4…”

Section: Introductionmentioning

confidence: 99%

Modification of the crystallographic parameters in a biomaterial employing a series of gamma radiation doses

Hossain

Shaikh

Rahaman

et al. 2022

Mol. Syst. Des. Eng.

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Synthesis and characterization of β-cyclodextrin/carboxymethyl chitosan/hydroxyapatite fused with date seed extract nanocomposite scaffolds for regenerative bone tissue engineering

Abstract: Herein, for the first time, heterojunctions containing nano-hydroxyapatite/carboxymethyl chitosan/β-Cyclodextrin fused with Date seed extract (DSE) were synthesized at different concentrations using co-precipitation to generate BCHD1, BCHD2, and BCHD3 nanocomposite scaffolds...

Cited by 10 publications

References 68 publications

3D-Printed Drug-Loaded Composite Scaffolds to Promote Osteogenesis and Antibacterial Activity

3D-Printed Drug-Loaded Composite Scaffolds to Promote Osteogenesis and Antibacterial Activity

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Modification of the crystallographic parameters in a biomaterial employing a series of gamma radiation doses

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