Ecmc 2022 2022
DOI: 10.3390/ecmc2022-13473
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Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones

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“…Chalcones and their skeletal system widely exist in many natural compounds and are a very attractive tool for the synthesis of different heterocyclic compounds [1–3] . Chalcones show various biological activities such as antioxidant, [4,5] antimicrobial, [6,7] anti‐infammatory, [8] antihypertensive, [9] antihistaminic, [10] anticancer [11] . Thiophene‐based chalcones also show many biological activities such as antibacterial, [12] anticancer (Figure 1, compound 1 ), [13] and enzyme inhibition (Figure 1, compound 2 ) [14–16] …”
Section: Introductionmentioning
confidence: 99%
“…Chalcones and their skeletal system widely exist in many natural compounds and are a very attractive tool for the synthesis of different heterocyclic compounds [1–3] . Chalcones show various biological activities such as antioxidant, [4,5] antimicrobial, [6,7] anti‐infammatory, [8] antihypertensive, [9] antihistaminic, [10] anticancer [11] . Thiophene‐based chalcones also show many biological activities such as antibacterial, [12] anticancer (Figure 1, compound 1 ), [13] and enzyme inhibition (Figure 1, compound 2 ) [14–16] …”
Section: Introductionmentioning
confidence: 99%
“…2a), a subclass of chalcones, are abundant in plants and widely present in various organisms, serving as precursors to flavonoids and several other heterocyclic pharmacophores. 22,23 These compounds have demonstrated a range of bioactivities, including anti-tubercular, anti-viral, anti-cancer, anti-inflammatory, anti-tumor, anti-fungal properties, and TYR inhibition. 24–26 The structural flexibility of chalcones allows for extensive modification, which can lead to enhanced biological activity and specificity.…”
Section: Introductionmentioning
confidence: 99%