Synthesis and comparative evaluation of the antioxidant activity for some new derivatives of 2,6-diisobornylphenol bearing an aminomethyl group at the position 4

Synthesis and Antioxidant Capacity of Some Derivatives of Sesamol at the C‐6 Position

“…To assess the antioxidant potential of the synthesized compounds 2 – 5 , 7a – 12 , we used an already established set of methods [13,15–21,36,37] . Sesamol ( 1 ) and the standard antioxidant BHT (2,6‐di‐ tert ‐butyl‐4‐methylphenol) [38,39] were taken as the most suitable reference compounds.…”

“…It should be noted that often we were unable to identify significant relationships between RSA (DPPH‐test) and the parameters obtained using the above test systems. This fact indicates that the ability to interact with radicals is an important, but not the sole mechanism responsible for the AOA compounds in relation to biomolecules and living cells [18,21] . It is known that, in addition to the role of radical occludents and/or metal chelators, antioxidant molecules, including sesamol ( 1 ), can exhibit surface‐active properties, which allow them to reduce the interfacial tension and create more stable reverse micelles in emulsions [3,40] .…”

“…The aim of this work was to synthesize and evaluate the antioxidant potential ( in vitro ) of sesamol derivatives at the C‐6 position, as well as to identify the most promising products for further studies among them. The presented study is a continuation of our work searching for effective antioxidants among derivatives based on natural and synthetic phenolic compounds [13–21] . In our study, a comprehensive assessment of the AOA of the derivatives was carried out using both simple and widespread methods (e. g., radical scavenging activity (RSA) in the DPPH‐test) and more biologically relevant approaches (such as the ability of compounds to inhibit the oxidation of a model substrate containing animal lipids, as well as to protect mammalian RBCs from death under conditions of acute oxidative stress).…”

Synthesis of new coumarin[1,3]oxazine derivatives of 7‐hydroxy‐6‐isobornyl‐4‐methylcoumarin and their antioxidant activity

“…The ability to interact with radicals is an important, but not the sole mechanism responsible for the AOA. The absence of a relationship between the results obtained in the test with DPPH and using other methods was also noted in previous works in the study of phenolic antioxidants (Buravlev et al, , 2021Samet et al, 2019), as well as other researches (Thaipong et al, 2006). The correct assessment of antioxidant activity should not be limited to studies of antiradical activity, and it is desirable to use more relevant biological test systems (Alam et al, 2013;Niki, 2010;Tabart et al, 2009;Takebayashi et al, 2010).…”

Exploring the antioxidant potential of chalcogen-indolizines throughout in vitro assays

“…The differences in the antioxidant effect against the synthetic radical DPPH observed for the chalcogen indolizines tested may be related to the structure–activity relationship (SAR) and the subsequent binding of substituents to the phenolic rings, since all compounds containing selenium showed antioxidant activity in the DPPH test, suggesting that the addition of selenium may be responsible for the ability to neutralize the DPPH radical. Moreover, compounds containing the methyl and fluorine groups linked to the phenolic rings have also demonstrated antioxidant activity against the DPPH radical ( Buravlev, Shevchenko & Kutchin, 2021 ; Dinesha et al, 2015 ), which may explain the antioxidant action of compounds SIN-3 and SIN-4.…”