Synthesis and Comparative Inotropic Effects of Several Isoquinoline Alkaloids

Khushmatov, Sh. S.; Zhumaev, I. Z.; Zhurakulov, Sh. N.; Saidov, A. Sh.; Виноградова, В. И.

doi:10.1007/s11094-020-02148-4

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2021

2024

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Cited by 5 publications

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“…Among the chemical compounds with heterocyclic structure, the alkaloids isoquinoline are considered to have a wide range of physiological effects [5].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Negative Inotropic Effects of a Isoquinoline Alkaloid N-14

Jumayev¹

2021

BRCR

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In studies, the alkaloid 1-(2-Chloro-4,5-methylenedioxyphenyl)-2-hydroxyethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (N-14) had a negative inotropic effect on the activity of the papillary muscle contraction of the rat heart detected. Ca2+ ions from SR play an important role in the process of contraction of the heart muscle. With this in mind, the negative inotropic effect of the N-14 alkaloid was investigated with the modification of the accumulation processes of Ca2+ ions to SR. To clarify this, we examined the effects of the alkaloid being studied on SERCA2a and RyR2. To do this, the inhibitor of SERCA2a - cyclopiazonic acid (CPA) and RyR activator caffeine, which provide the accumulation of Ca2+ ions in SR, were used.

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“…Among the chemical compounds with heterocyclic structure, the alkaloids isoquinoline are considered to have a wide range of physiological effects [5].…”

Section: Resultsmentioning

confidence: 99%