Synthesis and Complexation of Monotosylated 4-Aminopyridine with Nickel (II) and Iron (II) Ions

Orie, Kingsley John; Duru, Remy Ukachukwu; Ngochindo, R. I.

doi:10.7454/mss.v25i3.1242

Cited by 3 publications

(10 citation statements)

References 24 publications

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“…The complexes were soluble in DMSO, DMF, Acetic acid and ethanol whereas insoluble in water, hexane, acetone and ethyl acetate. This finding corroborates the investigation of [3,4]. The solubility of the compounds synthesized in some solvents depicts the interaction between the hydrogen ion in the complexes and the oxygen atom in the solvents which indicates the formation of a hydrogen bond (4).…”

Section: Solubility Analysis Of Ligand and Its Complexessupporting

confidence: 89%

“…The sharp melting points indicate fairly pure isolated compounds. These values were consistent with the melting points analysis of amidine sulphonamides and benzene sulphonamides by Abdul Qadir et al, [3] and the complexes of monotosylated 4-aminopyridine by Orie et al, [4]. The molar conductance of the complexes was determined in DMSO(10 -3 M).…”

Section: Physicochemical Analysis Of Ligand and Complexessupporting

confidence: 89%

“…The method adopted for the complexation of monotosylated 2-aminopyridine was by Orie et al, [4] and Duru et al, [5] with some modification. A hot ethanolic sulphonylated aminopyridine solution, C 12 H 12 N 2 O 2 S (2.0g, 806mmol) was placed in a boiled ethanolic solution of…”

Section: Complexation Of Heterocyclic Sulphonamide Derivatives Of 2-a...mentioning

confidence: 99%

“…Metal complexes are increasingly and commonly used as therapeutic compounds to treat several human diseases, such as infection, diabetes, anti-inflammatory issues and neurological disorders. Significant interest in the synthesis of metal complex-based drugs is currently observed in medicinal organic chemistry to address unique research, therapeutic and diagnostic opportunities [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…It is an important intermediate in the chemical industry, as well as in medicine manufacturing companies; owning to its usage in perfume, fragrances, dyes, pharmaceuticals, etc [11,20]. It is also an important transformation in medicinal chemistry because of the production of a drug molecule having multifunctional moieties (such as pyridine ring, benzene nucleus and sulphonamide) with vast applications [4].…”

Section: Introductionmentioning

confidence: 99%

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Metal Complexes of Heterocyclic Sulphonamide: Synthesis, Characterization and Biological Activity

Orie¹,

Duru²,

Ngochindo³

2021

SJAC

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The metal complex of heterocyclic sulphonamide with aminopyridine is a substantial class of pharmaceutical drugs used to treat infection, diabetes, anti-inflammatory issues and neurological disorders in the field of medicinal chemistry. The research reports the synthesis, characterization and biological activity of metal complexes of heterocyclic sulphonamide of aminopyridine. Sulphonamide of heterocyclic pyridine was synthesized by reacting 2-aminopyridine and tosyl chloride in an aqueous alkaline solution at ambient temperature. The iron (II) and copper (II) complexes of the ligand were also synthesized and recrystallized with suitable solvents, and the purity levels were ascertained with melting point and thin layer chromatographic pattern. Structural elucidation of the compounds was done via Nuclear Magnetic Resonance (NMR), Ultraviolet-Visible Spectroscopy (UV-VIS) Infrared (IR), Electrospray Ionization Mass Spectrometry (ESI-MS) Micro elemental analysis. Some absorption bands in the IR spectrum of heterocyclic sulphonamide derivatives were found to shift either to higher or lower wavenumbers in the complexes, indicating the involvement of azomethine nitrogen in coordination with the metal ion. The synthesized ligand and its metal complexes were screened for antimicrobial activity against Gram (-) Escherichia coli, Gram (-) Salmonella typhi, Gram (+) Staphylococcus aureus, Aspergillus flavus, Aspergillus niger and Saccharomyces cerevisiae. The ligand did not show activity against the selected bacterial and fungal strains whereas; some of the coordinated ligands gave a substantial improvement on their bactericidal and fungicidal activity. The complex of copper (II) was not bioactive to all the bacteria strains but sensitive to all the fungi strains. The complex of iron (II) was susceptible to the bacteria and fungi strains, except Aspergillus flavus that was inactive. When compared to Ciprofloxacin and Ketoconazole, with a broad-spectrum antibiotic, the standard antimicrobial agents were better in sensitivity than the synthesized compound.

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Section: Solubility Analysis Of Ligand and Its Complexessupporting

confidence: 89%

Section: Physicochemical Analysis Of Ligand and Complexessupporting

confidence: 89%

Section: Complexation Of Heterocyclic Sulphonamide Derivatives Of 2-a...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Metal Complexes of Heterocyclic Sulphonamide: Synthesis, Characterization and Biological Activity

Orie¹,

Duru²,

Ngochindo³

2021

SJAC

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Synthesis, Structural, Spectroscopic, Fluorescence, and Dielectric Studies of Bis-(4-Aminopyridine)-Zinc(II) Acetate: A Metal–Organic Crystal

Albert,

Priya,

Ahire

et al. 2023

J Fluoresc

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Synthesis of Bio-based Polyol Via Epoxidation and Hydroxylation of Shea Butter Fats

Emeka-Chioke,

Udeozo,

Nsude

et al. 2024

JACSI

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Polyols are mostly made from petroleum and other non-biodegradable fossil fuels, and as such, they are not environmentally benign. This study presents the process of making bio-based polyols from shea butter fats (SBF) by epoxidation and hydroxylation. Wet analysis, gas chromatography with flame-ionization detection (GC-FID), and Fourier transform infrared spectroscopy (FTIR) were all used to characterize the bio-based polyols. The acid number (13.92 mg KOH/g), iodine value (19.54 mg I2/100 g), saponification value (218.03 mg KOH/g), and viscosity (107.98 poise) suggest a good quality of synthesized SBF-polyol. The FTIR analysis of SBF-polyol indicates the existence of specific vibrational frequencies: 3473 cm-1 for hydroxyl (OH) groups, 2921–2854 cm-1, and 2929–2858 cm-1 for carbon-hydrogen (C-H) and methylene (CH2) groups, respectively, and 1748 cm-1 for carbonyl (-C=O) groups. The major unsaturated fatty acids detected in SBF were oleic acid, with an estimation of 10.41%; linoleic acid and linolenic acid were reported at 0.34% and 1.67%, respectively; however, they were absent in SBF-polyol. According to this data, bio-based polyols can be synthesized using SBF and are suggested for the production of top-notch polyols.

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Synthesis and Complexation of Monotosylated 4-Aminopyridine with Nickel (II) and Iron (II) Ions

Cited by 3 publications

References 24 publications

Metal Complexes of Heterocyclic Sulphonamide: Synthesis, Characterization and Biological Activity

Metal Complexes of Heterocyclic Sulphonamide: Synthesis, Characterization and Biological Activity

Synthesis, Structural, Spectroscopic, Fluorescence, and Dielectric Studies of Bis-(4-Aminopyridine)-Zinc(II) Acetate: A Metal–Organic Crystal

Synthesis of Bio-based Polyol Via Epoxidation and Hydroxylation of Shea Butter Fats

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