Synthesis and Crystal Structure of Tris(&lt;font size=-1&gt;L&lt;/font&gt;-&lt;i&gt;iso&lt;/i&gt;-leucinium(2&lt;i&gt;S&lt;/i&gt;,3&lt;i&gt;S&lt;/i&gt;))-dodecatungstophosphate 4.5 hydrate

One of the most attractive areas in inorganic chemistry is the synthesis of polyoxometalates (POMs) exhibiting new properties and applications. Since the impact of POMs in biochemistry and related fields of research has increased in the last few years, there has been a special interest in this topic. Significant progress in biological applications has been made where the interaction of POMs with amino acids, peptides and proteins is relevant. Versatile POMs play a series of different roles in the interaction with these biomolecules as described in this review. Various types of interactions are established, depending on the POM shape and charge, the amino acid side chain, peptide sequence or protein structure. Experimental conditions such as temperature, acidity, solvent, etc. are also important factors that influence the binding/reactivity of POM with biomolecules, as described herein. This understanding allows the adequate design of the POM-biomolecule couple for tailoring and controlling mechanisms of action such as catalysis, inhibition, and aggregation, or the crystallising agent.

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A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

Arefian

et al. 2017

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Structures ofN-acetyl-DL-isoleucine,N-acetyl-DL-alloisoleucine and their ammonium salts; role of ammonium ions in crystal structure formation

Yajima

Kimura

Hori

et al. 2016

Acta Crystallogr Sect B

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The crystal structures of N-acetyl-DL-isoleucine, N-acetyl-DL-alloisoleucine and their ammonium salts show that these four compounds exist as racemic compounds around room temperature. The two ammonium salts are arranged around a 21 screw axis, forming a helical column which consists of ammonium ions and single enantiomeric anions similar to the crystals of the ammonium salts of optically active N-acetyl-L-isoleucine and N-acetyl-D-alloisoleucine. The ammonium ion and the carboxylate ion in the helix are connected by three hydrogen bonds, the fourth hydrogen bond being formed between the ammonium ion and an external acetyl amino group of the neighboring helical column. The fourth hydrogen bond is formed between the ammonium ion and an external acetyl amino group of the neighboring 21 column. Ammonium N-acetyl-DL-alloisoleucinate was revealed to exist as an unstable racemic compound due to conformational similarity between the racemic and optically active compounds in the solid state and was optically resolved by fractional crystallization at 293 K.

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Synthesis and Crystal Structure of Tris(<font size=-1>L</font>-<i>iso</i>-leucinium(2<i>S</i>,3<i>S</i>))-dodecatungstophosphate 4.5 hydrate

Cited by 2 publications

References 6 publications

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

Structures ofN-acetyl-DL-isoleucine,N-acetyl-DL-alloisoleucine and their ammonium salts; role of ammonium ions in crystal structure formation

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