Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives

Eremina, Julia A.; Лидер, Е. В.; Kuratieva, Natalia V.; Самсоненко, Д. Г.; Klyushova, Lyubov S.; Sheven, D. G.; Trifonov, R. E.; Островский, В. А.

doi:10.1016/j.ica.2020.120169

Cited by 36 publications

(11 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As one can see from Figure S11, treatment of MCF-7 cells for 48 h with complex 3 initiated apoptosis (39%) and cell death (17%) after incubation with the highest tested compound concentration. The IC 50 value of complex 3 is 47.3 ± 0.8 µM, which is comparable to the IC 50 of cisplatin against this cell line (33.7 ± 1.8 µM) [27].…”

Section: Cytoxicity Evaluationsupporting

confidence: 57%

“…Cell viability was evaluated by Hoechst/PI staining by the standard method as previously described [27]. Human breast adenocarcinoma (MCF-7) and human hepatocellular carcinoma (HepG2) cell lines were seeded on 96-well plates at 6 × 10 3 cells per well and cultured in Iscove's Modified Dulbecco's Medium (IMDM, pH = 7.4) supplemented with a 10% fetal bovine serum under a humidified atmosphere (5% CO 2 and 95% air) at 37 • C. After 24 h, cells were treated with complexes 1-3.…”

Section: Cytotoxicity Studymentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Structural Characterization of Half-Sandwich Arene–Ruthenium(II) Complexes with Bis(imidazol-1-yl)methane, Imidazole and Benzimidazole

et al. 2021

View full text Add to dashboard Cite

Mono- and binuclear arene–ruthenium(II) complexes with imidazole-containing ligands were prepared by the reaction of the ligands (L1 = bis(imidazole-1-yl)methane; ImH = 1H-Imidazole; BImH = 1H-Benzimidazole) with [(p-cym)Ru(µ-Cl)2]2 dimers. When bis(imidazole-1-yl)methane reacted with [(p-cym)Ru(µ-Cl)2]2 in methanol, a binuclear complex of the type [Ru2(L1)2(p-cym)2Cl2]Cl2 (2) with cyclic structure was synthesized, whereas by using acetonitrile as a solvent under the same reaction conditions, an unexpected C–N bond cleavage was observed, and a complex of formula [Ru(ImH)2(p-cym)Cl]Cl (1) with coordinated imidazole molecules was obtained. Another type of arene–ruthenium complex [Ru(BImH)(p-cym)Cl2] (3) was obtained by the reaction of benzimidazole and [(p-cym)Ru(µ-Cl)2]2. All compounds were characterized by spectral (FT-IR, NMR 1H, 13C) and single-crystal X-ray diffraction methods; their catalytic activity in transfer hydrogenation and the cytotoxicity against MCF-7 and HepG2 cells were evaluated.

show abstract

Section: Cytoxicity Evaluationsupporting

confidence: 57%

Section: Cytotoxicity Studymentioning

confidence: 99%

Synthesis and Structural Characterization of Half-Sandwich Arene–Ruthenium(II) Complexes with Bis(imidazol-1-yl)methane, Imidazole and Benzimidazole

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Imidazole compounds, such as lansoprazole, ( R )-omeprazole, pantoprazole are suitable for the treatment of gastric ulcer, duodenal ulcer, reflux esophagitis; miconazole is a highly effective and safe broad-spectrum antifungal agent, which has effects on almost all pathogenic fungi. In addition, researchers have synthesized many imidazole and tetrazole derivatives, as well as their corresponding complexes, and investigated their structures, BSA/HAS binding abilities, and antitumor activities [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. For example, Cu(II) complexes [Cu(phen)(L) 2 ] and [Cu(dmphen)(L) 2 ] (HL = 5-benzyl-tetrazole, phen = 1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline) demonstrated the highest cytotoxicity against Hep2, HepG2, and MCF-7 [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Guo¹,

Wang³

et al. 2022

Molecules

View full text Add to dashboard Cite

Imidazole and tetrazole derivatives are widely used as clinical drugs since they possess a variety of pharmaceutical function. Zinc and iron are essential trace elements of the human body, with less toxicity and good biocompatibility. In this paper, two new essential metal mononuclear complexes [M(H2tmidc)2(H2O)2]·2H2O (M = Zn (1), Fe (2)) were synthesized through the reaction of 2-((1H-tetrazol-1-yl)methylene)-1H-imidazole-4,5-dicarboxylic acid (H3tmidc) and ZnSO4·7H2O or FeSO4·7H2O. The crystal structures were determined by means of the X-ray single crystal diffraction technique. Results from fluorescence investigations show that both complexes could interact with BSA as well as HSA through the static quenching mechanism. van der Waals forces and hydrogen bonds play important roles in the interaction of complexes and BSA/HSA since both ΔH and ΔS values are negative. The results of molecular docking are consistent with those in experimental studies. Furthermore, the anticancer activity of H3tmidc and both complexes against Eca-109 were preliminarily evaluated and the results show that both complexes have better anticancer activity than the corresponding ligand H3tmidc.

show abstract

“…The viability of the Hek293 cell line was evaluated with Hoechst 33342/propidium iodide staining by the standard method described in [ 20 ]. The cells were seeded on 96-well plates at 5 × 10 3 cells per well and cultured in Iscove’s modified Dulbecco’s medium (IMDM, pH = 7.4) supplemented with 10% fetal bovine serum in a CO 2 incubator at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Hydroxyapatite Double Substituted with Zinc and Silicate Ions: Possibility of Mechanochemical Synthesis and In Vitro Properties

et al. 2023

View full text Add to dashboard Cite

In this study, the mechanochemical synthesis of substituted hydroxyapatite (HA) containing zinc and silicon ions having a chemical formula of Ca10−xZnx(PO4)6−x(SiO4)x(OH)2−x, where x = 0.2, 0.6, 1.0, 1.5, and 2.0, was carried out. The synthesized materials were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and inductively coupled plasma spectroscopy. We found that HA co-substituted with zinc and silicate formed up to x = 1.0. At higher concentrations of the substituents, the formation of large amounts of an amorphous phase was observed. The cytotoxicity and biocompatibility of the co-substituted HA was studied in vitro on Hek293 and MG-63 cell lines. The HA co-substituted with zinc and silicate demonstrated high biocompatibility; the lowest cytotoxicity was observed at x = 0.2. For this composition, good proliferation of MG-63 osteoblast-like cells and an increased solubility compared with that of HA were detected. These properties allow us to recommend the synthesized material for medical applications, namely, for the restoration of bone tissue and manufacture of biodegradable implants.

show abstract

Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives

Cited by 36 publications

References 56 publications

Synthesis and Structural Characterization of Half-Sandwich Arene–Ruthenium(II) Complexes with Bis(imidazol-1-yl)methane, Imidazole and Benzimidazole

Synthesis and Structural Characterization of Half-Sandwich Arene–Ruthenium(II) Complexes with Bis(imidazol-1-yl)methane, Imidazole and Benzimidazole

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Hydroxyapatite Double Substituted with Zinc and Silicate Ions: Possibility of Mechanochemical Synthesis and In Vitro Properties

Contact Info

Product

Resources

About