Synthesis and cytostatic activity of acetylformamidoxime derivatives containing piperazine, hexahydrodiazepine, and dispirotripiperazinium residues

Kurmangalieva, R. G.; Poplavskaya, I. A.; Abdulin, K. A.; Andreyanova, T. A.; Safonova, T. S.

doi:10.1007/bf00770620

Cited by 2 publications

(1 citation statement)

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“…However, these compounds did not exhibit high activity [146]. The anticancer and antiproliferative activity of the O-ethers of pyrimidine oximes (e.g., compounds 114 and 115) have been widely investigated [147][148][149][150][151][152][153][154][155].…”

Section: Bactericidal Anticancer and Antiviral Activitymentioning

confidence: 99%

Oximes of six-membered heterocyclic compounds with two and three heteroatoms. II.* Reactions and biological activity (review)

Абеле

Golomba

et al. 2010

Chem Heterocycl Comp

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Data on the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives are reviewed. The synthesis of new heterocycles based on the oximes of six-membered heterocyclic compounds with two and three heteroatoms is considered separately. The principal results of research into the biological activity of these oximes and their ethers are also presented.The oximes of six-membered heterocyclic compounds with two and three heteroatoms are widely used as intermediates in fine organic synthesis. Their production methods and structural features were examined in the review [1]. In this article we discuss the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives. Methods for the synthesis of new heterocyclic systems from the derivatives of these oximes are considered in a separate section. In the last section some results from investigation of the biological activity of the ethers of these oximes are considered.

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Section: Bactericidal Anticancer and Antiviral Activitymentioning

confidence: 99%