Synthesis and cytotoxic activities of usnic acid derivatives

Bazin, Marc‐Antoine; Lamer, Anne-Cécile Le; Delcros, Jean‐Guy; Rouaud, Isabelle; Uriac, Philippe; Boustié, Joël; Corbel, Jean-Charles; Tomasi, Sophie

doi:10.1016/j.bmc.2008.05.069

Cited by 91 publications

(67 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to antibacterial activities, different studies have confirmed antiproliferative, antiviral, anti-inflammatory, and antiprotozoan activities of this molecule (Vijayakumar et al, 2000;De Carvalho et al, 2005;Fazio et al, 2007;Bazin et al 2008).…”

Section: Introductionmentioning

confidence: 84%

Antimycobacterial activity of usnic acid against resistant and susceptible strains ofMycobacterium tuberculosisand non-tuberculous mycobacteria

Ramos

Silva

2010

Pharmaceutical Biology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 84%

Antimycobacterial activity of usnic acid against resistant and susceptible strains ofMycobacterium tuberculosisand non-tuberculous mycobacteria

Ramos

Silva

2010

Pharmaceutical Biology

View full text Add to dashboard Cite

“…Usnic acid is the most ancient lichen compound also found in alpine species (Cladonia, Flavocetraria) and considered for antitumor activity with ten to hundred micromolar IC 50 units on several cancer cell lines (Bazin et al 2008). Apoptosis induction features have been revealed for usnic acid on L1210 cell lines (Bézivin et al 2004) through caspase 3 induction (Bazin et al 2008) but in cellular tests as for in vivo experiments, the solubilisation of this substance appear to be of importance.…”

Section: Cytotoxic Antimutagenic and Antitumor Activities For Potentmentioning

confidence: 97%

Bioactive lichen metabolites: alpine habitats as an untapped source

2010

Self Cite

View full text Add to dashboard Cite

International audienceLichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites. Some of these are forming an available biomass for phytochemical investigations, including the assessment of biological activities of the isolated compounds. The alpine or polar region are characterised by highly stressful environmental conditions for many organisms, but lichens are among the dominating organisms in these habitats. In the performant mutual protective system, lichen fungi often accumulate high amounts of metabolites with specific physicochemical properties (UV absorbents, hydrophobicity) which help the lichens to survive. Unique secondary metabolites and polysaccharides have been isolated and tested from these organisms. Even though this has been tested until now only with a low number of compounds so far, interesting activities have been recorded. We review here some of the antimicrobial, anti-inflammatory, antiproliferative and antioxidant activities properties described. Solutions with axenic biotechnological cultivation of each symbiotic partner and particularly the mycobiont to obtain the lichen secondary metabolites are challenging to overcome the limitations for the supply of these rare compounds. Additionally, these lichens appear to harbour a diversity of culturable microorganisms from which active compounds have also been isolated recently

show abstract

“…, is a yellow cortical pigment found only in lichens, occurring under two enantiomeric forms [7,8]. As previously reported, usnic acid is one of the most common and abundant lichen metabolites with interesting activities.…”

Section: Introductionmentioning

confidence: 99%

Validation of a UV-VIS Spectrophotometric method for the determination of usnic acid /collagen-based membranes

Nunes

Jesus²,

Bezerra³

et al. 2015

Scientia Plena

View full text Add to dashboard Cite

O ácido úsnico (AU) é um metabólito secundário de líquens que tem demonstrado potenciais efeitos farmacológicos, tais como atividade antimicrobiana, antiviral, antiproliferativa e anti-inflamatória. O colágeno, por sua vez, é um dos biomateriais mais utilizados visando o desenvolvimento de sistema de liberação de fármacos. Sendo assim, o objetivo deste estudo foi desenvolver e validar um método analítico por espectrofotometria na região do ultravioleta (UV) para determinação de concentrações de AU em membranas de colágeno. Os parâmetros de validação foram determinados de acordo com a Agência Nacional de Vigilância Sanitária (ANVISA). A especificidade revelou que os excipientes na formulação não interferiram na análise. A linearidade nas concentrações de 2-10 µg/mL apresentou um coeficiente de correlação de 0,9994. O método mostrou excelente repetibilidade (desvio-padrão relativo < 1,0%). A precisão revelou uma recuperação média percentual de 100,43%. O método foi robusto para a variação de temperatura e solvente. Os limites de detecção e de quantificação foram 0,109 e 0,364 g/mL, respectivamente. A taxa total de recuperação das membranas analisados apresentaram valores entre 100,4 e 83,2%.Palavras-chave: ácido úsnico, membranas de colágeno, espectrofotometria UV The usnic acid (UA) is a secondary metabolite of lichen that has shown potential pharmacological effects such as antimicrobial, antiviral, antiproliferative and anti-inflammatory activities. Collagen is one of the most useful biomaterials with various applications as drug delivery systems. The aim of this study was to develop and validate a quantitative UV spectrophotometric method for the determination of UA levels in collagen membranes. The validation parameters were assessed according to the Brazilian Health Surveillance Agency (ANVISA). The specificity revealed that the excipients in the formulation did not interfere with the analysis. The linearity in the range of 2-10 μg/mL presented a correlation coefficient of 0.9994. The method showed excellent repeatability (Relative Standard Deviation (RSD) < 1.0%). The accuracy revealed a mean percentage recovery of 100.43%. The method was robust for the variation of temperature and solvent. The detection and quantization limits were found at 0.109 and 0.364 µg/mL. The total rate recovery from the analyzed membranes showed values between 100.4 and 83.2%.

show abstract

Synthesis and cytotoxic activities of usnic acid derivatives

Cited by 91 publications

References 29 publications

Antimycobacterial activity of usnic acid against resistant and susceptible strains ofMycobacterium tuberculosisand non-tuberculous mycobacteria

Antimycobacterial activity of usnic acid against resistant and susceptible strains ofMycobacterium tuberculosisand non-tuberculous mycobacteria

Bioactive lichen metabolites: alpine habitats as an untapped source

Validation of a UV-VIS Spectrophotometric method for the determination of usnic acid /collagen-based membranes

Contact Info

Product

Resources

About