Synthesis and cytotoxic activity of isocembrol and its hydroxy derivatives

Салихов, Ш. М.; Файзуллина, Л. Х.; Валеев, Ф. А.

doi:10.1007/s11172-020-2981-6

Cited by 3 publications

(1 citation statement)

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“…Although these mechanisms are not entirely understood, they seem to be effective against glioblastoma, melanoma, leukemia, bone, breast, lung, ovary, pancreas, and prostate cancers [ 95 ]. The anti-proliferative and apoptotic effects of the thunbergol diterpene present in TO EO was confirmed in J82 (Blc) cell lines and human melanoma and renal UO-31 cancer cells [ 39 , 96 ]. Additionally, the plant used in our studies is considered to be an adjuvant drug in traditional therapies to enhance immunity [ 97 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant and Antiproliferative Activities of Taraxacum officinale Essential Oil

et al. 2022

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Taraxacum officinale (TO) has been historically used for medicinal purposes due to its biological activity against specific disorders. To investigate the antioxidant and the antiproliferativepotential of TO essential oil in vitro and in vivo, the chemical composition of the essential oil was analyzed by GC-MS. The in vivo antioxidant capacity was assessed on liver and kidney homogenate samples from mice subjected to acetaminophen-induced oxidative stress and treated with TO essential oil (600 and 12,000 mg/kg BW) for 14 days. The in vitro scavenging activity was assayed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the reducing power methods. The cytotoxic effects against the HeLa cancer cell line were analyzed. The GC-MS analysis showed the presence of 34 compounds, 8 of which were identified as major constituents. The TO essential oil protected mice’s liver and kidneys from acetaminophen-induced oxidative stress by enhancing antioxidant enzymes (catalase, superoxide dismutase, and glutathione) and lowering malondialdehyde levels. In vitro, the TO essential oil demonstrated low scavenging activity against DPPH (IC50 = 2.00 ± 0.05 mg/mL) and modest reducing power (EC50 = 0.963 ± 0.006 mg/mL). The growth of the HeLa cells was also reduced by the TO essential oil with an inhibition rate of 83.58% at 95 µg/mL. Current results reveal significant antioxidant and antiproliferative effects in a dose-dependent manner and suggest that Taraxacum officinale essential oil could be useful in formulations for cancer therapy.

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Section: Discussionmentioning

confidence: 99%