Synthesis and Cytotoxic Activity of Friedelinyl Esters
Leila R. Oliveira,
Diogo M. Vidal,
Túlio R. Freitas
et al.
Abstract:Commonly isolated from plants of Celastraceae family, pentacyclic triterpenoids have a broad spectrum of biological activities, such as antitumor, anti‐inflammatory, antinociceptive properties, among others. Structural modifications in these triterpenoids can enhance their biological activity, as well as their selectivity, while improving their physicochemical and pharmacokinetic aspects. In this study, eight novel esters were synthesized: four derivatives of 3α‐friedelinol (friedelan‐3α‐yl p‐bromobenzoate (1a… Show more
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