Synthesis and cytotoxic activity of 3-triarylmethylindoles

Synthesis and cytotoxic activity of 3-triarylmethylindoles. Part II. Chlorine-substitututed 3-triphenylmethylindoles

“…This very method was employed to obtain compounds Ia and II. However, in contrast to the reaction described in [1] where the process duration in boiling dioxane was about 2 h, the passage to chlorine-substituted lxiarylcarbinols led to a sharp drop in the reaction rate. For example, the synthesis of compound Ia required boiling the reaction mixture for over 10 h. For this reason, compounds Ib-Id were synthesized using a specially developed method of the indole tritylation with triphenylcarbinol in the melt in the presence of small amounts of ZnC12 [2].…”

“…In the previous work we proposed a method for the tritylation of indoles with triarylcarbinols in the presence of zinc chloride and molecular sieves [1]. This very method was employed to obtain compounds Ia and II.…”

Synthesis and cytotoxic activity of 3-triarylmethylindoles. III. 3-[Diphenyl(pyridyl)methyl]indoles

“…The triarylcarbinols listed in Table 1 and O-substituted triarylmethylindoles (5 -9) have been described in previous work [1,2]. …”