Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils in their racemic form

Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies

“…The synthesis involving uracil and benzaldehyde in literature ended up with a mixture of 5-(chloro(phenyl)methyl)pyrimidine-2,4(1 H ,3 H )-dione and bis(pyrimidine-2,4(1 H ,3 H )-diones). 52 The isolation of bis(pyrimidine-2,4(1 H ,3 H )-diones) as major product was unreported and this prompted us to delve deeper to design the synthetic strategy for these compounds as depicted in Scheme 1 . Here, the reaction between differently substituted aldehydes and uracil in 1 : 1 ratio in H 2 O with conc.…”

Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues

“…The synthesis of 5-[alkoxy-(4-nitrophenyl)methyl]uracils 124 (Scheme 21) has recently been investigated [34]. The authors reported the synthesis of alkoxy derivatives with alkyl chain lengths C 1 -C 12 whose preparation started with the condensation reaction of uracil and p -nitrobenzaldehyde in concentrated hydrochloric acid.…”

“…18) have been published [34–35]. All of the prepared compounds were tested for their cytotoxic activity in vitro against different cell lines and relationships between structure and cytotoxic activity were evaluated.…”

Synthesis, structural, conformational and DFT studies of N-3 and O-4 alkylated regioisomers of 5-(hydroxypropyl)pyrimidine

“…The development of new chemotherapeutic agents is becoming the major interest in many academic and industrial research laboratories all over the world with the aim to discover newer, more potent molecules with higher selectivity and reduced toxicity than the existing ones. Large arrays of uracil non-nucleoside derivatives possess variety of chemotherapeutic properties [1] including anticancer [2][3][4][5][6], antiviral [7][8][9][10][11][12][13][14][15] and antimicrobial activities [16]. Moreover, many purine and pyrimidine nucleoside analogues have been the object of intensive chemical and pharmacological investigation due to their potential anti-HIV activity [17].…”