Synthesis and cytotoxic effect of carbocyclic potential minor groove binders

Bartulewicz, Danuta; Anchim, Tomasz; Dąbrowska, Milena; Midura-Nowaczek, Krystyna

doi:10.1016/j.farmac.2003.11.005

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Other Symmetrical Structures1

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Cited by 6 publications

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“…Other molecules that interact with DNA have been reported in various studies on systems with peripheral chains containing benzene [98][99][100][101][102][103][104], pyridine [105] or naphthalene [106] rings. In order to obtain structure activity relationships, the authors considered the following points; the choice of substituents in the aryl rings and/or the flexibility and rigidity and/or substitution in the linker chain.…”

Section: Other Symmetrical Structuresmentioning

confidence: 98%

Molecular Symmetry: A Structural Property Frequently Present in New Cytotoxic and Proapoptotic Drugs

Sanmartín¹,

Font²,

Palop

2006

MRMC

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In recent years, a large number of new potent symmetrical cytotoxic agents that act through different mechanisms have been described. Apoptosis induction is one of the most representative of these mechanisms. Recent articles have revealed that the activation of apoptosis pathways is the key mechanism by which cytotoxic tumor cells are killed. The present review highlights the importance of the molecular symmetry of several chemical structures and their relation with cytotoxic and apoptotic activity.

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