Synthesis and cytotoxicity evaluation of gemcitabine-tobacco mosaic virus conjugates

Parhizkar, Elahehnaz; Rafieipour, Parivash; Sepasian, Alireza; Alemzadeh, Effat; Dehshahri, Ali; Ahmadi, Fatemeh

doi:10.1016/j.jddst.2021.102388

Cited by 4 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The history of virology identified the first virus, named the tobacco mosaic virus, in 1892. [10][11][12][13][14] The viruses have kept evolving since then in virology literature by incorporating sophisticated microscopes. 15,16 The world has become like a global village, and surveillance of the emergence and reappearance of regional epidemics or global pandemics rapidly spread transmittable diseases.…”

Section: Introductionmentioning

confidence: 99%

The Role of Social Media in the Advent of COVID-19 Pandemic: Crisis Management, Mental Health Challenges and Implications

Abbas¹,

Wang²,

et al. 2021

RMHP

276

160

View full text Add to dashboard Cite

Background: This study focuses on how educating people through social media platforms can help reduce the mental health consequences of the COVID-19 to manage the global health crisis. The pandemic has posed a global mental health crisis, and correct information is indispensable to dispel uncertainty, fear, and mental stress to unify global communities in collective combat against COVID-19 disease worldwide. Mounting studies specified that manifestly endless coronavirusrelated newsfeeds and death numbers considerably increased the risk of global mental health issues. Social media provided positive and negative data, and the COVID-19 has resulted in a worldwide infodemic. It has eroded public trust and impeded virus restraint, which outlived the coronavirus pandemic itself. Methods: The study incorporated the narrative review analysis based on the existing literature related to mental health problems using the non-pharmaceutical interventions (NPIs) approach to minimize the COVID-19 adverse consequences on global mental health. The study performed a search of the electronic databases available at PsycINFO, PubMed, and LISTA. This research incorporates the statistical data related to the COVID-19 provided by the WHO, John Hopkins University, and Pakistani Ministry of Health. Results: Pakistan reported the second-highest COVID-19 cases within South Asia, the fifthhighest number of cases in Asia after Iran, India, Russia, Saudi Arabia, and the 14th highest recorded cases, as of October 14, 2020. Pakistan effectively managed the COVID-19 pandemic in the second wave. It stands at the eighth-highest number of confirmed cases in Asia, the 3rd-highest in South Asia, and the 28th-highest number of established patients globally, as of February20, 2021. Conclusion:The COVID-19 has resulted in over 108.16 million confirmed cases, deaths over 2.374 million, and a recovery of 80.16 million people worldwide, as of February 12, 2021. This study focused on exploring the COVID-19 pandemic's adverse effects on global public health and the indispensable role of social media to provide the correct information in the COVID-19 health crisis. The findings' generalizability offers helpful insight for crisis management and contributes to the scientific literature. The results might provide a stepping-stone for conduct future empirical studies by including other factors to conclude exciting developments.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Social Media in the Advent of COVID-19 Pandemic: Crisis Management, Mental Health Challenges and Implications

Abbas¹,

Wang²,

et al. 2021

RMHP

276

160

View full text Add to dashboard Cite

show abstract

“…PVNPs can protect these cargoes from degradation and deliver them, which is conducive to their continued role. PVNPs can load small molecule drugs such as MTO [ 55 ], phenanthriplatin [ 59 , 70 ], gemcitabine [ 71 ] and cisPt [ 72 ], increase their accumulation within the tumor tissue, and induce tumor cytotoxicity. For example, loading DOX by CPMV [ 56 ], RCNMV [ 53 ], JgCSMV [ 73 ], or the prodrug DOX by PhMV-based VLPs [ 74 ] significantly improved antitumor efficacy in vitro and in vivo.…”

Section: Therapeutic Agent Deliverymentioning

confidence: 99%

Plant Virus Nanoparticles Combat Cancer

et al. 2023

View full text Add to dashboard Cite

Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatility of PVNPs is evident from their ability to be tailored to transport a range of therapeutic agents, including chemotherapy drugs, siRNA, and immunomodulators, thereby facilitating targeted delivery to the tumor microenvironment (TME). Furthermore, PVNPs may be customized with targeting ligands to selectively bind to cancer cell receptors, reducing off-target effects. Additionally, PVNPs possess immunogenic properties and can be engineered to exhibit tumor-associated antigens, thereby stimulating anti-tumor immune responses. In conclusion, the potential of PVNPs as a versatile platform for fighting cancer is immense, and further research is required to fully explore their potential and translate them into clinical applications.

show abstract

“…Therefore, various PVNPs have been developed and used for reducing these limitations. For example, loading mitoxantrone (MTO), a topoisomerase II inhibitor; phenanthriplatin, a cationic monofunctional DNA-binding platinum (II) complex; and gemcitabine, one of the nucleoside analog drugs, into tobacco mosaic virus (TMV) increased their accumulation within the tumor tissue and induced sufficient cytotoxicity toward MDA-MB-231, TNBC, and Michigan Cancer Foundation-7 (MCF7) cell lines [35,36]. In vivo MTO-TMV delivery in a mouse model of MDA-MB-231 xenografts reduced tumor growth, showing superior efficacy over free MTO [35].…”

Section: Small Molecule Drug Deliverymentioning

confidence: 99%

Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors

et al. 2022

View full text Add to dashboard Cite

Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms.

show abstract

Synthesis and cytotoxicity evaluation of gemcitabine-tobacco mosaic virus conjugates

Cited by 4 publications

References 23 publications

The Role of Social Media in the Advent of COVID-19 Pandemic: Crisis Management, Mental Health Challenges and Implications

The Role of Social Media in the Advent of COVID-19 Pandemic: Crisis Management, Mental Health Challenges and Implications

Plant Virus Nanoparticles Combat Cancer

Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors

Contact Info

Product

Resources

About