2002
DOI: 10.1016/s0960-894x(01)00831-9
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Synthesis and Cytotoxicity of 3,4-Diaryl-2(5H)-furanones

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Cited by 86 publications
(34 citation statements)
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“…The IR spectra of 3a,b,c show N-H stretching bands at 3377, 3374, 3379 cm -1 and O-H stretching bands at 3146, 3161, 3170 cm -1 (broad), respectively. The structures of 3a-c were confirmed by nmr spectroscopic data that agree with those found for the similar compounds [2,3,9,17]. In the 1 H nmr spectra of 3a, 3b and 3c the characteristic shifts of CH 3 protons adjacent to the ring at 1.86, 1.84, 1,84 ppm, CH 3 C=O protons at 2.46, 2.49, 2.48 ppm, NH protons 7.27, 7.25, 7.29 were observed, respectively.…”
supporting
confidence: 79%
See 1 more Smart Citation
“…The IR spectra of 3a,b,c show N-H stretching bands at 3377, 3374, 3379 cm -1 and O-H stretching bands at 3146, 3161, 3170 cm -1 (broad), respectively. The structures of 3a-c were confirmed by nmr spectroscopic data that agree with those found for the similar compounds [2,3,9,17]. In the 1 H nmr spectra of 3a, 3b and 3c the characteristic shifts of CH 3 protons adjacent to the ring at 1.86, 1.84, 1,84 ppm, CH 3 C=O protons at 2.46, 2.49, 2.48 ppm, NH protons 7.27, 7.25, 7.29 were observed, respectively.…”
supporting
confidence: 79%
“…IR data of compounds (3a-c) and a tentative assignment of the some of the frequencies, which are made by comparison of related compounds described in literature [2,3,9,17], are listed in Table 1. The IR spectra of 3a,b,c show N-H stretching bands at 3377, 3374, 3379 cm -1 and O-H stretching bands at 3146, 3161, 3170 cm -1 (broad), respectively.…”
mentioning
confidence: 99%
“…Many cis-restricted analogs of CA-4 have been synthesized to improve the solubility, stability, and therapeutic index 4 of these drugs. A number of examples where the olefinic group is replaced by a conformationally restricted ring structure have demonstrated significant antiproliferative activity 13 , including those based on coumarin (1) 14,15 , 2(5H)-furanone (2) 16 , imidazole 17 , 1,3-oxazole (3) 17 , furazan (4) 4 and furan (5) 18 , diarylindole 17,19 , and arylthioindole 20 , illustrated in Figure 1. We have previously reported the application of the benzoxepin 21 and benzothiepin scaffolds 22 for the design of antiproliferative agents as estrogen receptor (ER) antagonists.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, most modifications of combretastatins have been directed to ring B and the ethenyl bridge. Modifications of ring B have included, but have not been limited to, different substitutions on the phenyl, heteroaromatic or heterocyclic rings [21]- [24], and the unstable ethenyl bridge is substituted either with sulfonate ( Figure 1) [25] [26], chalcone [27] [28], imidazole [29], triazole [30] [31], furazan [32], pyrazole or 1,3-thiazole [33] derivatives.…”
Section: Introductionmentioning
confidence: 99%