Synthesis and Cytotoxicity Studies of Cyclohepta[b]indoles, Benzo[6,7]Cyclohepta[1,2-b]Indoles, Indeno[1,2-b]Indoles, and Benzo[a]Carbazoles

Abstract

Synthesis and biological evaluation of various tricyclic and tetracyclic indoles are described. A number of these compounds possess in vitro activity against human nasopharyngeal carcinoma (HONE-1) and gastric adenocarcinoma (NUGC-3) cell lines.

Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

“…After washing with 1% acetic acid, the stain was solubilized with 10 mM unbuffered Tris base, and the absorbance was measured on a Bio-Tek microplate reader. Dose-response parameters were calculated, as reported in the literature [ 32 ].…”

Biological importance of the indole nucleus in recent years: A comprehensive review

“…The series of various tricyclic and tetracyclic indoles synthesized by Hong et al . were evaluated for their anticancer activity where the compounds 16 , 17 , 18 , and 19 were found to exhibit highest in vitro activity against human nasopharyngeal carcinoma (HONE‐1) and gastric adenocarcinoma (NUGC‐3) cell lines [10]. …”

Synthesis of Indoles via Intermolecular and Intramolecular Cyclization by Using Palladium-Based Catalysts

“…A five-membered pyrrole ring and benzene are fused to form indole [1]. Indoles are important heterocyclic compounds because they are an integral part of many alkaloids and biologically active compounds [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Thus, having enormous activities, indole has always acquired the attention of researchers.…”

“…Such a method of using a combination of reagents and two-phase catalysts increased the yield dramatically. The reaction mechanism was initiated with 2-[(trimethyl)ethynyl]aniline (9) formation via Sonogashira coupling of trimethylsilylacetylene (7) with 2-iodoaniline (6). The second step afforded ethynylaniline (10) by desilylation.…”