Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols

Abstract

Linear and star shaped polyglycidols (synonym with polyglycerols) are prepared in a controlled ring opening polymerization of protected glycidols. Beside the molar mass and the polydispersity, the architecture of the polyglycidols is controlled by using mono-and multifunctional monoand polydispers initiators. Copolymers of dissimilarly protected glycidols as well as copolymers with nonfunctional oxiranes were prepared by means of anionic polymerization while copolymers of protected glycidol with tetrahydrofuran were prepared by means of cationic polymerization. Polyethers with functional groups in the side chains (functional polyethers) with special emphasis on polyglycidols (containing hydroxymethyl groups in the side chains) were used to prepare multifunctional polymers and (hetero)grafted polymer brushes via chemical and enzyme catalyzed reaction. The potential of poly(glycidol-graft-e-caprolactone)-co-glycidol) prepared via enzyme catalyzed grafting of polyglycidols using e-caprolactone as a monomer and Lipase B from Candida antarctica as a catalyst is presented. Finally, comparative degradation studies of densely and loosely grafted polyglycidols are presented and discussed.

A Comparison of Gallium and Indium Alkoxide Complexes as Catalysts for Ring-Opening Polymerization of Lactide

“…Metal alkoxide species, M-OR, have been shown to be the true active species in numerous ROP processes. [1][2][3][4][5][6][7][8][9][10][11][12][13][18][19][20][21][22][23][24] For example, in 2004, Lewiński and co-workers reported the first structurally characterized aluminum ε-caprolactone complex, indicating that the Al-Me group has poor reactivity with CL. 77 Thus, in most ROP cases, an alcohol is used as an initiator and is essential in order to start the polymerization.…”

Redox Control of Aluminum Ring-Opening Polymerization: A Combined Experimental and DFT Investigation

“…On the other hand, based on previous reports, [5][6][7][8][9][10][11][12][13][18][19][20][21][22][23][24][25][26][27] after the insertion of the first equivalent of other monomers (CL, VL, and TMC), the rates of polymerization will not decrease remarkably, indicating that the insertion of the first monomers will not cause such a significant chelation effect like LA. Thus, in these cases, the energy of the initiation step can be used to estimate the energy of propagation.…”

Polyglycidol Based Amphiphilic Double‐Comb Copolymers and Their Self‐Association in Aqueous Solution

“…[16][17][18] A variety of functional polyglycidols were synthesized in our group by post polymerization modification of the hydroxymethyl groups obtained after deprotection or by conversion of the phenyl carbonate groups prepared as intermediates. [19][20][21][22] Based on these results we concluded that polyglycidols fulfill the prerequisites of being suitable precursors for the synthesis of amphiphilic doublecomb polymers via the grafting-onto strategy.…”