Synthesis and degradation properties of $\boldsymbol{\beta} $ -TCP/BG porous composite materials

Fan, Xiaohui; Chen, Jian; Ruan, Jianming; Zhou, Zhiyong; Zou, Jianpeng

doi:10.1007/s12034-011-0072-x

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…In terms of the size effect of bone grafts on bone regeneration, macroscopic bone grafts generally provide more free space than their microscopic counterparts for cells to move into and attach to, thereby promoting vascularization and ingrowth of newly formed bone tissue into the bone grafts [33]. As shown in Figure 3A,B, Bontree ® 1.0-granule was associated with greater amounts of newly formed bone tissues than the Bontree ® 0.5-granule at both 4 and 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

et al. 2021

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Bone grafts used in alveolar bone regeneration can be categorized into autografts, allografts, xenografts, and synthetic bones, depending on their origin. The purpose of this study was to evaluate the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree®) in vitro, in vivo, and in clinical cases. Material characterization of Bontree® granules (0.5 mm and 1.0 mm) using scanning electron microscopy and X-ray diffraction showed that both 0.5 mm and 1.0 mm Bontree® granules were uniformly composed mainly of OCP. The receptor activator of NF-κB ligand (RANKL) and alkaline phosphatase (ALP) activities of MG63 cells were assessed and used to compare Bontree® with a commercial biphasic calcium phosphate ceramic (MBCP+TM). Compared with MBCP+TM, Bontree® suppressed RANKL and increased ALP activity. A rabbit tibia model used to examine the effects of granule size of Bontree® grafts showed that 1.0 mm Bontree® granules had a higher new bone formation ability than 0.5 mm Bontree® granules. Three clinical cases using Bontree® for ridge or sinus augmentation are described. All eight implants in the three patients showed a 100% success rate after 1 year of functional loading. This basic research and clinical application demonstrated the safety and efficacy of Bontree® for bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

et al. 2021

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“…BG, first discovered by Hench in 1969 [14,15], forms inorganic-like thin layers of hydroxyapatite (HAp) at the junction with bone through which it spontaneously bonds. The degradation rate of pure β-TCP material is faster than that of β-TCP/BG-composited materials [16].…”

Section: Introductionmentioning

confidence: 91%

Fabrication and Characterization of Granulated β-Tricalcium Phosphate and Bioactive Glass Powders by Spray Drying

Nakanishi,

Ningsih,

Putra

et al. 2024

J. Compos. Sci.

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Biocomposite materials are widely implemented in various applications in clinical dentistry and orthopedics since it is possible to combine multiple materials by relying on their compatibility. Ceramic-based materials have osteogenic and osteoconductive features owing to their inorganic constituents with dental and bone tissue. β-tricalcium phosphate (β-TCP) and bioactive glass have excellent biocompatibility, bioresorbability, and bioactivity. In this study, β-TCP and BG powders were fabricated by spray pyrolysis (SP) and spray drying (SD). These fabrication methods are suitable for the mass production and synthesis of spherical particles. At first, β-TCP and BG spherical particles were synthesized by SP and characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and scanning electronic microscopy (SEM). After that, these powders were granulated with the different weight ratios of β-TCP/BG = 100/0, 75/25, 50/50, 25/75, and 0/100 by SD. The resulting granulation powders were characterized using XRD, FT-IR, and SEM to investigate phase compositions and microstructures. In addition, cytotoxicity was investigated using the MTT assay.

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“…BGs are more bioactive than calcium phosphate compounds; in addition, the silicabased BGs bioactivity reactions are faster than hydroxyapatite (HA). One of the most important characteristics of BGs is that they can provide an ideal environment for genetic control and stimulation of human osteoblasts to be proliferated and di erentiated as they lead to bone formation both in vitro and in vivo with rapid bone regeneration [1,14,15]. There are two processing methods for synthesizing BGs: traditional melt quenching and versatile sol-gel methods.…”

Section: Introductionmentioning

confidence: 99%

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

Soltani-Dehnavi

Mehdikhani-Nahrkhalaji

Rafienia

et al. 2017

Scientia Iranica

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Abstract. The purpose of this study is to evaluate the antibacterial activity and cytotoxicity of copper-doped (Cu45SBG) and copper-free bioactive glass (45SBG) nanopowders. The antibacterial e ect was studied using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. The BG nanopowders were synthesized by the sol-gel technique. They were characterized by various techniques and their cytotoxicity was evaluated by MTT assay. Chemical compositions of BGs were as the same as the predicted compositions. The size of the BGs with an amorphous structure was measured to be around 100 nm. Both BG nanopowders have no antibacterial e ect on broth concentrations less than 12.5 mg/ml. They demonstrated similar antibacterial activity on E. coli with Minimum Bactericidal Concentration (MBC) of 12.5 mg/ml. Cu45SBG nanopowders with the MBC of 25 mg/ml were more e cient on S. aureous bacteria than 45SBG nanopowders with the MBC of 50 mg/ml. Compared to 45SBG, Cu45SBG showed much more cytotoxicity. 45SBG demonstrated similar cells viability to the control. It was concluded that to overcome cytotoxic e ect, Cu content of BGs nanopowders must be lower than the amount used in this research. Therefore, 45SBG nanopowders with considerable antibacterial activity could be used as a good candidate for biomedical applications.

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Synthesis and degradation properties of $\boldsymbol{\beta} $ -TCP/BG porous composite materials

Cited by 3 publications

References 37 publications

Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

Fabrication and Characterization of Granulated β-Tricalcium Phosphate and Bioactive Glass Powders by Spray Drying

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

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