Synthesis and delivery activity of new cationic cholesteryl glucosides

Chitosan and its derivatives as nanocarriers for siRNA delivery

“…c) Targetability: cell-type specific delivery has been tackled using targeting moieties or ligands either tagged directly to siRNA or to the siRNA carrier [10,39]. These may include antibodies [40,41], ligands [42,43], aptamers of other DNA/RNA hybrids [44] and peptides [45]. d) Cellular uptake and intracellular trafficking: challenging barriers impair siRNA delivery to the target tissue.…”

N,N,N-Trimethyl-N-(methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosid-5-yl)ammonium 4-methylbenzenesulfonate sesquihydrate

“…Recent years have witnessed a resurgence of interest in the synthesis of QACs, especially their sugar derivatives, which have potential biological properties (Abel et al, 2002;Blizzard et al, 2002;Honda et al, 1988;Thomas et al, 2009;Maslov et al, 2010).…”

“…For QAC sugar derivatives, see: Abel et al (2002); Blizzard et al (2002); Honda et al (1988); Thomas et al (2009) ;Maslov et al (2010); Dmochowska et al (2006Dmochowska et al ( , 2009Dmochowska et al ( , 2011Pellowska-Januszek et al (2004); Skorupa et al (2004). For related synthetic methods, see: Gosh & Liu (1996); Sairam et al 2003; Sarabia-Garcia & Lopez-Herrera (1996); Dibrov et al (2010).…”

Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships

“…The significant transfection activity attained was attributed to an improved cell binding and uptake of the lipoplexes promoted by the presence of cholesterol (Crook et al, 1998) and/or better stability of the lipoplex in serum (Simberg et al, 2003). In 1991, Gao et al reported the synthesis and application of the cholesterol-based cationic lipid 3-β-[N-(N′,N′-dimethylaminoethyl)carbamoyl]-cholesterol (DC-Chol, 1a), which was combined with DOPE to transfect mammalian cells (Gao & Huang, 1991 (Zhdanov et al, 1998;Gao & Hui, 2001;Geall et al, 2000;Percot et al, 2004;Ding et al, 2008;Medvedeva et al, 2009;Maslov et al, 2010). The cationic amphiphiles containing cholesterol as a hydrophobic residue possess a high transfection activity and a low toxicity, finding use in the studies of both the structure-activity relationships and membrane fusion mechanisms Kearns et al, 2008).…”