Synthesis and DNA cleavage properties of ternary Cu(II) complexes containing histamine and amino acids

Reddy, P. Rabindra; Rao, Kandibanda S.; Satyanarayana, B.

doi:10.1016/j.tetlet.2006.08.033

Cited by 52 publications

(21 citation statements)

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“…The calculated intrinsic binding constant (K b = 1.35 Â 10 5 M -1 ) and red shift suggested a strong binding of 1 with DNA, possibly by intercalation, as compared to other metal complexes described in the literature. [75][76][77][78] …”

mentioning

confidence: 99%

Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

et al. 2009

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The design and development of suitable biomimetic catalytic systems capable of mimicking the functional properties of enzymes continues to be a challenge for bioinorganic chemists. In this study, we report on the synthesis, X-ray structures, and physicochemical characterization of the novel isostructural [Fe III Co ] complex as the catalytically active species in diester hydrolysis reactions. Kinetic studies on the hydrolysis of the model substrate bis(2,4-dinitrophenyl)phosphate by 1 and 2 show Michaelis-Menten behavior, with 2 being 35% more active than 1. In combination with k H /k D isotope effects, the kinetic studies suggest a mechanism in which a terminal M III -bound hydroxide is the hydrolysis-initiating nucleophilic catalyst. In addition, the complexes show maximum catalytic activity in DNA hydrolysis near physiological pH. The modest reactivity difference between 1 and 2 is consistent with the slightly increased nucleophilic character of the Ga

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confidence: 99%

Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

et al. 2009

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“…From the absorption titration data, the binding constant (Kb) of the complex was determined from eqn. [DNA], Kb is given by the ratio of slope to intercept [17].…”

Section: Dna Binding Studiesmentioning

confidence: 99%

Synthesis, Characterization, Thermal degradation, X-Ray and DNA Binding Studies on Metal(II) and Mixed Metal Hydrazone Glyoxylate Dihydrates: A Typical One Step Aqueous Condensation Reaction

Pradeep¹,

Sivasankar²

2017

Asian J. Chem.

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INTRODUCTIONCondensation of aldehydes with simple and higher molecular weight amines conducted in non-aqueous medium to extract hydrazides. Imines and substituted imines type Schiff's base ligands have been revealed to possess stronger coordination ability resulting in an emerging interest. It is well known that imines are not very stable compounds and are easy to hydrolyze. Hence, synthesis of free imine type Schiff"s base ligands in the metal free environment with high yield becomes more difficult due to their side polymerization reactions. One effective method to fix this problem involves an 'in situ' reaction. In other words, the metal ion acts as a templating agent, directing the condensation without polymerization.Research and review of literature show that the pH values play a vital role in determining the type of complexes formed during the course of the reaction. When the pH is between 5 and 6, the ligand does not ionize and mostly adopts the neutral (H2O)2] were assigned on the basis of hydrazine and metal analyses and further characterized by magnetic susceptibility measurements, UV-visible, infrared, 1 H and 13 C NMR and D2O exchange spectra, simultaneous TG-DTA analyses and X-ray powder diffraction techniques. The magnetic moments and UV-visible spectra indicate that these complexes are of high-spin octahedral geometry. The infrared spectra reveal the monodentate coordination of carboxylate ions and coordination of water molecules. The TG-DTA traces are in accordance with the formation of respective metal oxide as the end product after initial dehydration and further pyrolyses of the anhydrous complexes. The Xray powder diffraction patterns indicate the isomorphism among the series of complexes. In these complexes the metal ions are octahedrally surrounded by two bidentate hydrazoneglyoxylate ions and two water molecules. The isomorphism among the series of complexes has been exploited in the preparation of mixed metal complexes. The mixed metal complex when heated to 300 °C in a pre-heated silica crucible undergoes autocatalytic decomposition to yield respective metal cobaltite, MCo2O4 as the final residue. The formation of the mixed metal complexes and metal cobaltites are confirmed by their infrared spectra and X-ray powder diffraction patterns. TG-DTA of the complexes also supports the formation of metal cobaltites. The particle size and SEM analyses of simple oxides and mixed metal oxides were carried out for further application of these metal cobaltites as catalysts. The interaction of Zn(II) complex with calf thymus DNA was investigated by absorption spectra. The DNA binding affinity of Zn(II) complex is 2.60 × 10 4 M -1 which reveals the strong binding affinity.

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“…One of the most important DNA-related activity of the transition metal complexes is that, some of the complexes show the ability to cleave DNA. Very recently, Cu(II) complexes have been reported to be active in DNA strand scission 4 . Studies on the interaction of transition metal complexes with DNA continue to attract the attention of researchers due to their importance in design and development of synthetic restriction enzymes, chemotherapeutic drugs and DNA foot printing agents 5 .…”

Section: Natarajan Raman and Abraham Selvanmentioning

confidence: 99%

Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical properties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: synthesis and spectral characterization

Raman¹,

Selvan²

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Synthesis and DNA cleavage properties of ternary Cu(II) complexes containing histamine and amino acids

Cited by 52 publications

References 45 publications

Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

Synthesis, Characterization, Thermal degradation, X-Ray and DNA Binding Studies on Metal(II) and Mixed Metal Hydrazone Glyoxylate Dihydrates: A Typical One Step Aqueous Condensation Reaction

Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical properties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: synthesis and spectral characterization

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Synthesis and DNA cleavage properties of ternary Cu(II) complexes containing histamine and amino acids

Cited by 52 publications

References 45 publications

Unsymmetrical FeIIICoII and GaIIICoII Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

Unsymmetrical FeIIICoII and GaIIICoII Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

Synthesis, Characterization, Thermal degradation, X-Ray and DNA Binding Studies on Metal(II) and Mixed Metal Hydrazone Glyoxylate Dihydrates: A Typical One Step Aqueous Condensation Reaction

Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical properties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: synthesis and spectral characterization

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Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)

Unsymmetrical Fe^IIICo^II and Ga^IIICo^II Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs)