Synthesis and dual D2and 5-HT1Areceptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones

Ullah, Nisar

doi:10.3109/14756366.2013.776556

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…[1][2][3][4][5][6][7][8][9][10][11] The classical approaches to preparet hese molecules are based on the use of toxic reactants, such as phosgenea nd its derivatives or oxalyl chloride and its derivatives. [1][2][3][4][5][6][7][8][9][10][11] The classical approaches to preparet hese molecules are based on the use of toxic reactants, such as phosgenea nd its derivatives or oxalyl chloride and its derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…Ureas, oxamides, 2-oxazolidinones,a nd benzoxazolones are important carbonyl derivatives. [1][2][3][4][5][6][7][8][9][10][11] The classical approaches to preparet hese molecules are based on the use of toxic reactants, such as phosgenea nd its derivatives or oxalyl chloride and its derivatives. [12] Recently,t he possibility to synthesize these important compounds directly by the catalytic oxidative carbonylation of amines or b-aminoa lcohols has been explored extensively.…”

Section: Introductionmentioning

confidence: 99%

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Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

et al. 2015

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The direct syntheses of ureas, oxamides, 2-oxazolidinones, and benzoxazolones by the oxidative carbonylation of amines, β-amino alcohols, and 2-aminophenols allows us to obtain high value added molecules, which have a large number of important applications in several fields, from very simple building blocks. We have found that it is possible to perform these transformations using the PdI2 /KI catalytic system in an ionic liquid, such as 1-butyl-3-methylimidazolium tetrafluoroborate, as the solvent, the solvent/catalyst system can be recycled several times with only a slight loss of activity, and the product can be recovered easily by crystallization.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

et al. 2015

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“…In addition to the above-mentioned 1,4-DACA, some specific fragments were used as primary pharmacophores, namely 7piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-one, 778 5-piperidinyl and 5-piperazinyl-1H-benzo[d]midazole-2(3H)-one, 779 4-(1-benzimidazolinone)piperidine, 780 sumanirole, 489,490,776,777 tranylcypromine, 472 pramipexole, 469 2phenylcyclopropylmethylamine, 527 eticlopride, 479,775 1,2,3,4-tetrahydro-3-quinolinamine, 776 tetracyclic, 781 tetrahydroisoquinoline, 480,498,594,595,600,[782][783][784][785][786][787] or 1,3-disubstituted morpholine. 438,474,490,493,788 Various aliphatic, 477,515,516,602,[789][790][791][792][793] bicyclic [794][795][796][797] or spirocyclic 798 amines have also been used for amine moiety.…”

Section: Primary Pharmacophorementioning

confidence: 99%

Recent advances in dopamine D₂ receptor ligands in the treatment of neuropsychiatric disorders

Jůza

Musílek

Mezeiová

et al. 2022

Medicinal Research Reviews

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Dopamine is a biologically active amine synthesized in the central and peripheral nervous system. This biogenic monoamine acts by activating five types of dopamine receptors (D 1-5 Rs), which belong to the G protein-coupled receptor family. Antagonists and partial agonists of D 2 Rs are used to treat schizophrenia, Parkinson's disease, depression, and anxiety. The typical pharmacophore with high D 2 R affinity comprises four main areas, namely aromatic moiety, cyclic amine, central linker and aromatic/heteroaromatic lipophilic fragment. From the literature reviewed herein, we can conclude that 4-(2,3-dichlorophenyl), 4-(2-methoxyphenyl)-, 4-(benzo[b]thiophen-4-yl)-1-substituted piperazine, and 4-(6fluorobenzo[d]isoxazol-3-yl)piperidine moieties are critical for high D 2 R affinity. Four to six atoms chains are optimal for D 2 R affinity with 4-butoxyl as the most pronounced one. The bicyclic aromatic/heteroaromatic systems are most frequently occurring as lipophilic appendages to retain high D 2 R affinity. In this review, we provide a thorough overview of the therapeutic potential of D 2 R modulators in the treatment of the aforementioned disorders. In addition, this review summarizes current knowledge about these diseases, with a focus on the dopaminergic pathway underlying these pathologies. Major attention is paid to the structure, function, and pharmacology of novel D 2 R ligands, which have been developed in the last decade (2010-2021), and belong to the 1,4-disubstituted aromatic cyclic amine group. Due to the abundance of data,

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Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies

Mansha

Kumari

Cournia

et al. 2016

European Journal of Medicinal Chemistry

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Synthesis and dual D₂and 5-HT_1Areceptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones

Cited by 8 publications

References 28 publications

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

Recent advances in dopamine D₂ receptor ligands in the treatment of neuropsychiatric disorders

Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies

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Synthesis and dual D2and 5-HT1Areceptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones

Cited by 8 publications

References 28 publications

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones

Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders

Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies

Contact Info

Product

Resources

About

Synthesis and dual D₂and 5-HT_1Areceptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones

Recent advances in dopamine D₂ receptor ligands in the treatment of neuropsychiatric disorders