Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives

Abstract

One-pot reaction of 1 with ethyl cyanoacetate and/or benzylidenemalono-nitrile afforded pyridazine derivatives 2 and 3, respectively. Compound 2 was subjected to some reactions to produce other new pyridazine derivatives. Also, treatment of 2 with hydrazine hydrate in ethanol gave the carbohydrazide 7. Some derivatives of the latter compound have been synthesized. Cyclic voltammograms of compounds 2, 5b, 7 and 8b using an undivided cell at platinum electrodes are discussed. The antimicrobial activity of some synthesized derivatives has been investigated.

Synthesis of a Novel 1,4-Dicarbonyl Scaffold – Ethyl 3-Formyl-4,5-dihydrofuran-2-carboxylate – and Its Application to the Synthesis of Pyridazines

“…Apart from their numerous applications as therapeutic agents, molecules based on the pyridazine nucleus have been significant research targets in recent chemical innovation areas such as supramolecular chemistry, metal catalysis, 29 chemiluminescent materials, and nonlinear optical…”