Synthesis and Electrochemical Studies of Hexamethyldibenzotetraaza N4-Macrocyclic Complexes of Ni(II) and Cu(II) Metal ions

Abstract

Hexamethyldibenzotetraaza[14]annulene type macrocyclic complexes of Ni(II) and Cu(II) have been synthesized by template method. These macrocyclic complexes were characterized by molar conductance, elemental analysis, IR, UV-visible, mass spectra and cyclic voltammetry. On the basis of electronic studies saddle shape distorted octahedral structure have been assigned to these macrocyclic complexes. The redox behaviour of Ni(II) and Cu(II) macrocyclic complexes showed reversible and quasi-irreversible redox process that supported by the ipc/ipa ratio which is in good agreement with Randles-Sevcik equation. These macrocyclic complexes were also studied for the antimicrobial activity against E. coli, P. aeruginosa, B. subtilis, S. aureus and C. albicans compared with gentamycin as standard drug.

Synthesis of Co(II) and Ni(II) Asymmetric Tetraazamacrocyclic Complexes and Their Electrochemical and Antimicrobial Studies

“…Previously, comprehensive research on the development of macrocyclic complexes has evolved with particular respect to their antibacterial activity. Transition metal macrocyclic complexes were extensively examined for their antimicrobial and anticancer properties [16][17][18][19].…”

“…Recently, transition metals such as cobalt and nickel have been used for synthesis of complexes with diverse ligand and studied for their diverse properties [5][6][7][8]. In the early electrochemical studies of tetraazamacrocyclic complexes, the factors that influence the development of both oxidized and reduced metal species were identified [9][10][11]. It has been revealed that the overall redox activities of a particular system are determined by the following factor: (i) macrocyclic ring size, (ii) the ligand charge, (iii) the type of the ligand substituents, and (iv) degree of ligand unsaturation.…”