Synthesis and electrochemical study of complexes of 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4H-imidazol-4-ones with transition metals (Co, Ni, and Cu). Molecular structures of CuIIL1Cl2 (L1 is (5Z)-2-methylthio-3-phenyl-5-(α-pyridylmethylidene)-3,5-dihydro-4H-imidazol-4-one) and CoIIL2Cl2 (L2 is (5Z )-3-methyl-2-methylthio-5-(α-pyridylmethylidene)-3,5-dihydro-4H-imidazol-4-one)

Abstract

Synthesis and electrochemical study of complexes of 2 methylthio 5 (pyridylmethylidene) 3,5 dihydro 4H imidazol 4 oneswith transition metals (Co, Ni, and Cu). Molecular structures of Cu II L 1 Cl 2 (L 1 is (5Z ) 2 methylthio 3 phenyl 5 (α α α α α pyridylmethylidene) 3,5 dihydro 4H imidazol 4 one) and Co II L 2 Cl 2 (L 2 is (5Z ) 3 methyl 2 methylthio 5 (α α α α α pyridylmethylidene) 3,5 dihydro 4H imidazol 4 one)New transition metal (Ni II , Co II , and Cu II ) complexes with 2 methylthio 5 (pyridyl methylidene) 3,5 dihydro 4H imidazol 4 ones were synthesized by the reaction of 5 (α , β , or γ )pyridyl substituted 2 methylthio 3,5 dihydro 4H imidazol 4 ones with MCl 2 •nH 2 O. In the complexes with α Py substituted ligands, the metal atom has a tetrahedral coordination environment and is coordinated by the nitrogen atoms of the pyridine and thiohydantoin rings and two chloride anions. The results of electronic spectroscopy and magnetic susceptibility measurements suggest that the complexes with the β and γ Py substituted ligands have poly meric structures, and the metal atoms in these complexes are in an octahedral environment. The molecular and crystal structures of Cu II L 1 Cl 2 (L 1 is (5Z) 2 methylthio 3 phenyl 5 (α pyridylmethylidene) 3,5 dihydro 4H imidazol 4 one) and Co II L 2 Cl 2 (L 2 is (5Z ) 3 me thyl 2 methylthio 5 (α pyridylmethylidene) 3,5 dihydro 4H imidazol 4 one) were estab lished by X ray diffraction. Semiempirical quantum chemical calculations were performed for 2 methylthio 5 (pyridylmethylidene) 3,5 dihydro 4H imidazol 4 ones. The complexes, start ing ligands, and metal chlorides were studied electrochemically. The mechanism of electro oxidation and electroreduction of 2 methylthio 5 (pyridylmethylidene) 3,5 dihydro 4H imidazol 4 ones and their cobalt, nickel, and copper complexes was proposed.Mn II , 16 Cs I , 14 Tl III , 21 Zn II , Cd II , and Hg II , 17 V III , V IV , and V V ions 18 are few in number, whereas data on com plexes of S alkylated thiohydantoins are, to our knowl edge, lacking.The aim of the present study was to synthesize com plexes of divalent Co, Ni, and Cu ions with isomeric α , β , and γ pyridyl (5Z ) 2 methylthio 3 phenyl 5 (pyridylmethylidene) 3,5 dihydro 4H imidazol 4 ones and the Co complex with (5Z ) 3 methyl 2 methylthio 5 (α pyridylmethylidene) 3,5 dihydro 4H imidazol 4 one and investigate these complexes by electrochemical methods. Recently, we have developed a convenient pro cedure for the synthesis of such complexes. 23-25

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity

“…dose of 170 mg/kg (o.d., 10 days) in P388-inoculated mice, Table S3: Acute toxicity study design for compound 29, Table S4: Dynamics of body weight of mice in the study of acute toxicity of compound 29, Table S5: Average group indicators of the relative mass of the internal organs of mice in the study of acute toxicity of the compound 29 . References [ 85 , 86 ] are cited in Supplementary Materials.…”

"Anti-Halogen" Bonds as a Factor Determining the Tetrahedral Structure of Copper in Its Complexes With (5z, 5'z)-2,2'- (Ethane-1,2-Diyldisulfanyldiyl)bis(5-(2-Pyridylmethylene)-3-Allyl-3,5-Dihydro- 4h-Imidazole-4-One)

“…Среди них найдены соединения с антиаритмической и антигипертензивной активностями, антивирусным, фунгицидными и гербицидным действием, антибластомными и антитромботическими свойствами и рядом других активностей. В работе [1] был…”