Synthesis and electrophysiological characterization of cyclic morphiceptin analogues

Pil, Joost; Veken, Pieter Van der; Bal, Gunther; Augustyns, Koen; Haemers, Achiel; Tytgat, Jan

doi:10.1016/j.bcp.2004.02.011

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Cited by 3 publications

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Tuning the Stereoselectivity in One‐Pot Scission/Addition Processes: Synthesis of Azanucleotide Analogues from Proline Derivatives

2013

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The one‐pot preparation of azanucleotide analogues from proline derivatives has been achieved by a sequential radical decarboxylation/phosphorylation process. The process proceeded under mild conditions, giving high yields of the nucleotide analogues. Remarkably, the stereoselectivity of the reaction can be controlled by using different oxygen and nitrogen substituents at C‐4 to give preferentially either the 2,4‐cis or 2,4‐trans products. In this way, the diastereomeric cis/trans ratio can be shifted from 98:2 to 15:85.

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Tuning the Stereoselectivity in One‐Pot Scission/Addition Processes: Synthesis of Azanucleotide Analogues from Proline Derivatives

2013

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Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors

Florentino

Silva

Cardoso

et al. 2019

Biomedicine & Pharmacotherapy

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Dipeptidyl Peptidases: Substrates and Therapeutic Targeting in Human Health and Disease

Wilson

Abbott

2011

Proteinases as Drug Targets

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Enzymatic members of the dipeptidyl peptidase (DP) 4-like gene family have been implicated in a wide range of diseases including type II diabetes, rheumatoid arthritis, wound healing and cancer. DP4 is a clinically validated target for the treatment of type II diabetes. Evidence supporting the role of DPs in immune function is increasing such that the development of further targeted therapeutics seems promising. Elucidation of DP substrates will help to reveal additional roles for this unique protease family, opening the door for further therapeutic avenues. Here, we provide an introduction to the biochemical properties of DP4, fibroblast activation protein (FAP), DP8 and DP9, and discuss their biological substrates, physiological roles, and the potential for therapeutic targeting of this family.

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Synthesis and electrophysiological characterization of cyclic morphiceptin analogues

Cited by 3 publications

References 22 publications

Tuning the Stereoselectivity in One‐Pot Scission/Addition Processes: Synthesis of Azanucleotide Analogues from Proline Derivatives

Tuning the Stereoselectivity in One‐Pot Scission/Addition Processes: Synthesis of Azanucleotide Analogues from Proline Derivatives

Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors

Dipeptidyl Peptidases: Substrates and Therapeutic Targeting in Human Health and Disease

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