Synthesis and employment of PEGDA for fabrication of superhydrophilic PVDF/PEGDA electrospun nanofibrous membranes by in-situ visible photopolymerization

Ashjari, Hamid Reza; Ahmadi, Arsalan; Dorraji, Mir Saeed Seyed

doi:10.1007/s11814-017-0260-5

Cited by 24 publications

(9 citation statements)

References 34 publications

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“… 12 Among the materials used for blending with PVDF, amphiphilic copolymers have shown good compatibility with the PVDF matrix and are deemed as successful blending additives. 13 , 14 Several amphiphilic copolymers were synthesized using atom transfer radical polymerization (ATRP), and then blended with membrane materials. 12 , 15 − 17 Specifically, PVDF- graft -poly(ethylene glycol) methyl ether methacrylate (PVDF- g -PEGMA) is a derived amphiphilic copolymer synthesized using ATRP, which was blended with PVDF to enhance the hydrophilicity, flux, and antifouling performance of PVDF membranes.…”

Section: Introductionmentioning

confidence: 99%

Superwettable PVDF/PVDF-g-PEGMA Ultrafiltration Membranes

Tiraferri

et al. 2020

ACS Omega

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Poly(vinylidene fluoride) (PVDF) is a common and inexpensive polymeric material used for membrane fabrication, but the inherent hydrophobicity of this polymer induces severe membranes fouling, which limits its applications and further developments. Herein, we prepared superwettable PVDF membranes by selecting suitable polymer concentration and blending with PVDF- graft -poly(ethylene glycol) methyl ether methacrylate (PVDF- g -PEGMA). This fascinating interfacial phenomenon causes the contact angle of water droplets to drop from the initial value of over 70° to virtually 0° in 0.5 s for the best fabricated membrane. The wetting properties of the membranes were studied by calculating the surface free energy by surface thermodynamic analysis, by evaluating the peak height ratio from Raman spectra, and other surface characterization methods. The superwettability phenomenon is the result of the synergetic effects of high surface free energy, the Wenzel model of wetting, and the crystalline phase of PVDF. Besides superwettability, the PVDF/PVDF- g -PEGMA membranes show great improvements in flux performance, sodium alginate (SA) rejection, and flux recovery upon fouling.

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Section: Introductionmentioning

confidence: 99%

Superwettable PVDF/PVDF-g-PEGMA Ultrafiltration Membranes

Tiraferri

et al. 2020

ACS Omega

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“…The structure of the NPs was examined by 1 H-NMR and ATR-FTIR and was fully consistent with the proposed structure. The 1 H-NMR spectra presented in Figure 2 illustrated that the signals appeared at 5.9, 6.2, and 6.6 ppm in the PEGDA spectrum were attributed to the vinyl groups of the molecule, whereas peaks at 2.7 and 4.4 ppm belonged to the alkyl chain and methylene groups adjacent to the ether group, respectively [ 28 , 29 ]. The vinyl group of AA was shown as doublets at 6.0, 6.3, and 6.7 ppm.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Polyethylene Glycol Diacrylate/Acrylic Acid Nanoparticles as Nanocarriers for the Controlled Delivery of Doxorubicin to Colorectal Cancer Cells

et al. 2022

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Doxorubicin (Dox) is known for its potential to deliver desirable anticancer effects against various types of cancer including colorectal cancer. However, the adverse effects are serious. This study aimed to synthesize polyethylene glycol diacrylate (PEGDA)/acrylic acid (AA)-based nanoparticles (PEGDA/AA NPs) for Dox delivery to colorectal cancer cells. The NPs were synthesized using free-radical polymerization reaction using the monomers PEGDA and AA with their physical properties, drug loading and release, biocompatibility, and anticancer effect evaluated. The NPs were spherical with a size of around 230 nm, with a 48% Dox loading efficiency and with loading capacity of 150 µg/mg. Intriguingly, the NPs had the ability to prolong the release of Dox in vitro over 24 h and were non-toxic to intestinal epithelial cells. Dox-loaded PEGDA/AA NPs (Dox-NPs) were able to effectively kill the colorectal cancer cell line (HT-29) with the Dox-NPs accumulating inside the cell and killing the cell through the apoptosis pathway. Overall, the synthesized PEGDA/AA NPs exhibit considerable potential as a drug delivery carrier for colon cancer-directed, staged-release therapy.

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“…The mechanical properties of biomaterials can be controlled by various methods [28]. Therefore, a drug delivery carrier made by electrospinning can contain a desired quantity of drug and can control the drug release behavior through temperature, pH, and UV irradiation [23,24,26,29,30].…”

Section: Introductionmentioning

confidence: 99%

“…Our results show that drug release is regulated by the crosslinking degree of the lidocaine-loaded alginate/CMC/PEO film. The drug release behavior was confirmed by HPLC, and, as a result, an excellent anti-adhesion barrier was developed that can be applied to treat patients in the medical field.Polymers 2020, 12, 618 2 of 13 through temperature, pH, and UV irradiation [23,24,26,29,30].Crosslinking generally involves forming links between two polymer chains using crosslinking agents. These links include covalent and ionic bonds.…”

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confidence: 99%

Development of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film and Application as an Anti-Adhesion Barrier

Baek

Park

et al. 2020

Polymers

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Surgery, particularly open surgery, is known to cause tissue/organ adhesion during healing. These adhesions occur through contact between the surgical treatment site and other organ, bone, or abdominal sites. Fibrous bands can form in unnecessary contact areas and cause various complications. Consequently, film-and gel-type anti-adhesion agents have been developed. The development of sustained drug delivery systems is very important for disease treatment and prevention. In this study, the drug release behavior was controlled by crosslinking lidocaine-loaded alginate/carboxymethyl cellulose (CMC)/polyethylene oxide (PEO) nanofiber films prepared by electrospinning. Lidocaine is mainly used as an anesthetic and is known to have anti-adhesion effects. Our results show that drug release is regulated by the crosslinking degree of the lidocaine-loaded alginate/CMC/PEO film. The drug release behavior was confirmed by HPLC, and, as a result, an excellent anti-adhesion barrier was developed that can be applied to treat patients in the medical field.Polymers 2020, 12, 618 2 of 13 through temperature, pH, and UV irradiation [23,24,26,29,30].Crosslinking generally involves forming links between two polymer chains using crosslinking agents. These links include covalent and ionic bonds. Therefore, the control of crosslinking density is generally used to regulate the physical properties of polymers, such as drug release profiles. Numerous studies have been conducted on the regulation of drug release behavior by controlling the degree of crosslinking of drug carriers [31][32][33]. Scheme 1. Schematic of the postsurgical tissue/organ adhesion process and the role of the antiadhesion barrier.

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Synthesis and employment of PEGDA for fabrication of superhydrophilic PVDF/PEGDA electrospun nanofibrous membranes by in-situ visible photopolymerization

Cited by 24 publications

References 34 publications

Superwettable PVDF/PVDF-g-PEGMA Ultrafiltration Membranes

Superwettable PVDF/PVDF-g-PEGMA Ultrafiltration Membranes

Synthesis of Polyethylene Glycol Diacrylate/Acrylic Acid Nanoparticles as Nanocarriers for the Controlled Delivery of Doxorubicin to Colorectal Cancer Cells

Development of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film and Application as an Anti-Adhesion Barrier

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