Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters

Buchholz, Viola; Agarwal, Seema; Greiner, Andreas

doi:10.1002/mabi.201500279

Cited by 17 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As is well known, side alkyl groups, randomly distributed along the linear main chain, contribute to increase the material flexibility, reducing the crystallizing macromolecular chain ability [32,33]. Poly(butylene succinate) is too rigid for flexible food packaging, due to its high crystallinity degree: copolymerization with a glycol containing enough long side alkyl groups could represent an efficient tool to improve the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Novel Random PBS-Based Copolymers Containing Aliphatic Side Chains for Sustainable Flexible Food Packaging

et al. 2017

View full text Add to dashboard Cite

Abstract:In the last decade, there has been an increased interest from the food packaging industry toward the development and application of biodegradable and biobased plastics, to contribute to the sustainable economy and to reduce the huge environmental problem afflicting the planet. In this framework, the present paper describes the synthesis of novel PBS (poly(butylene succinate))-based random copolymers with different composition containing glycol sub-units characterized by alkyl pendant groups of different length. The prepared samples were subjected to molecular, thermal, diffractometric and mechanical characterization. The barrier performances to O 2 , CO 2 and N 2 gases were also evaluated, envisioning for these new materials an application in food packaging. The presence of the side alkyl groups did not alter the thermal stability, whereas it significantly reduced the sample crystallinity degree, making these materials more flexible. The barrier properties were found to be worse than PBS; however, some of them were comparable to, or even better than, those of Low Density Polyethylene (LDPE), widely employed for flexible food packaging. The entity of variations in the final properties due to copolymerization were more modest in the case of the co-unit with short side methyl groups, which, when included in the PBS crystal lattice, causes a more modest decrement of crystallinity degree.

show abstract

Section: Introductionmentioning

confidence: 99%

Novel Random PBS-Based Copolymers Containing Aliphatic Side Chains for Sustainable Flexible Food Packaging

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Aliphatic polyesters have also been proposed for cell encapsulation (Cameron and Shaver, 2011) but its mechanical instability and difficult to tune permeability due to its biodegradability (Buchholz et al, 2016) has limited its application. Poly (lactic-co-glycolic acid) (PLGA) is a linear, polymerized aliphatic polyester that may overcome some issues as it possesses better biostability (Angelova and Hunkeler, 1999).…”

Section: Attenuate Host Responses By Rational Choices For Polymersmentioning

confidence: 99%

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

Vos

2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in semipermeable but immunoprotective polymeric membranes. The technology allows for successful transplantation of insulin-producing cells in the absence of immunosuppression. Different approaches of immunoisolation are currently under development. These approaches involve intravascular devices that are connected to the bloodstream and extravascular devices that can be distinguished in micro- and macrocapsules and are usually implanted in the peritoneal cavity or under the skin. The technology has been subject of intense fundamental research in the past decade. It has co-evolved with novel replenishable cell sources for cure of diseases such as Type 1 Diabetes Mellitus that need to be protected for the host immune system. Although the devices have shown significant success in animal models and even in human safety studies most technologies still suffer from undesired tissue responses in the host. Here we review the past and current approaches to modulate and reduce tissue responses against extravascular cell-containing micro- and macrocapsules with a focus on rational choices for polymer (combinations). Choices for polymers but also choices for crosslinking agents that induce more stable and biocompatible capsules are discussed. Combining beneficial properties of molecules in diblock polymers or application of these molecules or other anti-biofouling molecules have been reviewed. Emerging are also the principles of polymer brushes that prevent protein and cell-adhesion. Recently also immunomodulating biomaterials that bind to specific immune receptors have entered the field. Several natural and synthetic polymers and even combinations of these polymers have demonstrated significant improvement in outcomes of encapsulated grafts. Adequate polymeric surface properties have been shown to be essential but how the surface should be composed to avoid host responses remains to be identified. Current insight is that optimal biocompatible devices can be created which raises optimism that immunoisolating devices can be created that allows for long term survival of encapsulated replenishable insulin-producing cell sources for treatment of Type 1 Diabetes Mellitus.

show abstract

“…In addition, the polymer structure is often intentionally designed and synthetized in the way of faster degradability for these applications. The degradability of aliphatic polyesters generally increases with a lower content of the crystalline structure and it can be done by the introduction of irregularities to the polymeric structure e.g., by the presence of the side groups [137].…”

Section: Polyesters With Stimuli-sensitive Linkagesmentioning

confidence: 99%

Selectively Biodegradable Polyesters: Nature-Inspired Construction Materials for Future Biomedical Applications

Urbánek

Jäger

et al. 2019

Polymers

View full text Add to dashboard Cite

In the last half-century, the development of biodegradable polyesters for biomedical applications has advanced significantly. Biodegradable polyester materials containing external stimuli-sensitive linkages are favored in the development of therapeutic devices for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These selectively biodegradable polyesters degrade after particular external stimulus (e.g., pH or redox potential change or the presence of certain enzymes). This review outlines the current development of biodegradable synthetic polyesters materials able to undergo hydrolytic or enzymatic degradation for various biomedical applications, including tissue engineering, temporary implants, wound healing and drug delivery.

show abstract

Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters

Cited by 17 publications

References 23 publications

Novel Random PBS-Based Copolymers Containing Aliphatic Side Chains for Sustainable Flexible Food Packaging

Novel Random PBS-Based Copolymers Containing Aliphatic Side Chains for Sustainable Flexible Food Packaging

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

Selectively Biodegradable Polyesters: Nature-Inspired Construction Materials for Future Biomedical Applications

Contact Info

Product

Resources

About