Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands

Visible-Light-Driven Silver-Catalyzed One-Pot Approach: A Selective Synthesis of Diaryl Sulfoxides and Diaryl Sulfones

“…Aryl sulfoxides and aryl sulfones are useful building blocks of numerous organic compounds and drug candidates and have exhibited many significant biological activities. , They can act as prostaglandin D 2 antagonists, proton pump inhibitors, antidepressants, as well as anti-inflammatory and antibacterial agents (Figure ). ,, What is more, diaryl sulfoxides and diaryl sulfones have shown promising antitumor and antifungal properties as well as HIV-1 reverse transcriptase inhibitor activity. ,,, …”

Convenient and Inexpensive Route to Sulfonylated Pyridines via SNAr Reaction of Electron-Rich Pyridines by Iron Catalysis

“…[2][3][4][5][6][7][8] Among these, aryl sulfones and sulfonylated pyridines are highlighted as an important class of versatile and useful compounds. 9,10 Additionally, these pyridines play an important role as directing groups for further functionalization as applied to complex molecule synthesis. [11][12][13][14][15][16][17] General methods to access sulfonylated pyridines include the oxidation of thiol ethers, [18][19][20] coupling reactions, 21,22 and S N Ar chemistry.…”

Cu(I)-Catalysed coupling of Arylsulfinic Salts with Aryl Bromides

“…Diaryl sulfones possess versatile properties and are indispensable not only in organic synthesis 1,2 but also in the pharmaceutical industry. [3][4][5] Recently, transition-metalcatalysed cross-coupling reactions have emerged as powerful tools for the construction of building blocks in a large number of compounds used as pharmaceuticals. 6,7 Sodium arylsulfinate has been used as an important aryl sulfonyl reagent to afford diaryl sulfones via cross-coupling with aromatic iodides, 8,9 aryl triflates, 10,11 diaryliodonium salts [12][13][14][15] and aryl boronic acids [16][17][18][19][20][21][22] (Fig.…”