“…In light of these findings, the next goal of scientists has been to introduce new quinone-containing compounds by offering new opportunities for the development of selective agents in the treatment of cancer. Recent studies from our research group Yildirim et al, 2017) and that of Ferreira (Dias et al 2018), Ryu (Ryu, Song, Lee, Hong, Yoon, & Kim, 2010;Ryu, Yoon, Song, Im, Kim, & Kim, 2012), Tandon (Tandon, Maurya, Kumar, Rashid, & Panda, 2014;Tandon et al, 2010), and Valderrama (Valderrama, Ibacache, Rodriguez, Theoduloz, & Benites, 2011;Valderrama, Leiva, Rodriguez, Theoduloz, & Schmeda-Hirshmann, 2008) have shown that electrophilic character of 1,4-quinones can undergo with neutral and/or anionic nucleophiles in different conditions in versatile reactions, thus leading to various biologically active (hetero)cyclic quinone structures for their pharmacological properties. In this regard, as a result of the immense value of quinone compounds in organic and medicinal chemistry, 1,4-quinones have been studied for over a half-century as an important class of building blocks and still continue to attract considerable attention due to the broad range of synthetic and medicinal applications Johnson-Ajinwo et al, 2018;Pingaew et al, 2015;Ravichandiran, Kannan, Ramasubbu, Muthusubramanian, & Samuel, 2016;Ravichandiran, Subramaniyan, et al, 2019;Tandon & Kumar, 2013;Valderrama et al, 2016;Wellington, 2015).…”