Synthesis and Evaluation of 5‐HT<sub>2A</sub> and 5‐HT<sub>2C</sub> Receptor Binding Affinities of Novel Pyrimidine Derivatives.

Bozsing, D.; Simonek, Ildikó; Simig, Gyula; Jakoczi, Ivan; Szikora, István; Levay, Gyoergy; Tihanyi, Károly; Schmidt, Éva

doi:10.1002/chin.200308137

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Piperazine Containing Structure1

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2006

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“…Therefore, with the aim to obtain selective agents for 5-HT 2C or 5-HT 2A receptor, they prepared a variety of compounds structurally related to 373 (Table 41) [43]. Introduction of a methyl group at the 2-position on the benzyl group linked to the piperazine (compound 374) led to significant increase in 5-HT 2C receptor affinity, whereas the presence of a methyl in 4-position was less tolerated.…”

Section: Piperazine Containing Structurementioning

confidence: 99%

Selective Agents for Serotonin2C (5-HT2C) Receptor

Lacivita¹,

Leopoldo

2006

CTMC

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The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes non-patent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.

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Section: Piperazine Containing Structurementioning

confidence: 99%