Synthesis and evaluation of antibacterial activity of water-soluble copper, nickel and zinc tetra (n-carbonylacrylic) aminephthalocyanines

Synthesis of new zinc (II) phthalocyanine conjugates with block copolymers for cancer therapy

“…Strong absorptions at 3330 and 3206 cm -1 in the FT-IR spectrum of 4 were attributed to stretching vibrations of peripheral amine groups, while a strong absorption at 1604 cm -1 was contributed to their bending vibrations. Generally, peaks observed in the FT-IR spectra of compound 4 were nearly the same as for very similar nickel tetraaminophthalocyanine, described by Pavaskar et al 18 The chemical identity of the obtained zinc tetraaminophthalocyanine 4 was additionally confirmed by 1 H NMR analysis, which revealed signals from aromatic protons at 8.05-9.65 ppm confirming the presence of aromatic moieties characteristic for phthalocyanine structures. The desired compound was obtained in very good yield (over 90%), exceeding the yields of similar nickel tetraaminophthalocyanine (about 61%), synthesized by Pavaskar et al.…”

“…The first method needs relatively fewer reaction steps, so is usually preferred. 18 A convenient starting material for zinc phthalocyanine possessing peripheral amine groups is zinc tetranitrophthalocyanine, obtained upon heating 4-nitrophthalimide with an appropriate catalyst, metal salt (e.g. zinc chloride or acetate) and urea.…”

“…zinc chloride or acetate) and urea. The latter derivative can be easily reduced to zinc tetraaminophthalocyanine utilizing sodium sulfide 18 or hydrazine. 17 An additional advantage of this procedure is that 4-nitrophthalimide is conveniently prepared by nitration of phthalimide.…”

“…17 An additional advantage of this procedure is that 4-nitrophthalimide is conveniently prepared by nitration of phthalimide. 19 Poly(ethylene oxide), a nonionic compound commonly used to enhance water solubility or dispersability of many substances, can be attached to zinc tetraaminophthalocyanine by two approaches: zinc tetraaminophthalocyanine transformation to zinc tetra(N-carbonylacrylic)aminophthalocyanine utilizing reaction with maleic anhydride, 18 followed by coupling with poly(ethylene glycol) or synthesis of carboxyl group terminated poly(ethylene glycol) that can react directly with zinc tetraaminophthalocyanine. Both synthetic routes can be conducted utilizing Steglich esterification or its amide modification -a general method of preparation of labile esters or amides under very mild conditions.…”

UV‐Light Photoelectrochemical Sensor Based on the Copper Tetraamino‐Phthalocyanine‐modified ITO Electrode for the Detection of Nifedipine in Drugs and Human Serum

“…The characteristic functional groups of CuTAPc were identified by FT‐IR spectroscopy (Figure (a)). A double peak was observed in the wavelength range of 3500–3200 cm −1 that corresponds to the presence of amino groups (ν NH2 ) . The sharp peak at 1606 cm −1 (δ NH ) further proved the presence of amino groups .…”