Synthesis and evaluation of antibacterial, anti-fungal, anti-inflammatory properties of silver nanoparticles mediated via roots of Smilax aspera

Negi, Aayasha; Vishwakarma, Rahul Kumar; Negi, Devendra Singh

doi:10.1016/j.matpr.2022.01.203

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Similarly, extract of Adiantum incisum has also been reported to show antidiabetic activities in vivo as well (Bilal et al, 2022). Silver nanoparticles from root extracts of Smilax aspera have shown antibacterial, anti-fungal and anti-inflmmatory activities (Negi et al, 2022). Flavonoids from bryophytes like Marchantia polymorpha have shown strong hepatoprotective activity (Zhang et al, 2022) while the endophytes from the same plant have shown anticancer potential (Stelmasiewicz et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Potential of Extracts of Selected Medicinal Plants from Nepal

Pant,

Joshi,

Aryal

2024

Tribhuvan University Journal

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Aqueous and metholic extracts of twelve different species of antidiabetic plants belonging to different plant groups (liverworts, ferns and flowering plants) were screened for the presence of seven different groups of secondary metabolites. The same extracts were also subjected to quantification of total phenolic and flavonoid content. Antioxidant potential of those extracts was also compared using DPPH radical scavenging activity. The qualitative phytochemical assessment showed presence of more phytochemicals in methanol extracts than aqueous extracts. Furthermore, the extracts of none of the species possessed all the phytochemicals tested. The methanolic extracts also contained quantitatively more metabolites like total phenolics and total flavonoids than aqueous extracts. The highest value of total phenolic content (TPC) and total flavonoid content (TFC) were found respectively in methanol extracts of Rhus succedanea (162.71 ± 0.23 mg GAE/g) and Asterella wallichiana (70.5 ± 0.58 mg QE/g). The lowest value of TPC (17.86 ± 0.3 mg GAE/g) and TFC (2.63 ± 0.34 mg QE/g) was found in aqueous extracts of Hedychium coronarium. DPPH radical scavenging activity revealed high antioxidant potential in species with relatively high TPC values like O. wallichii, Rhus chinensis, R. succedanea, Rubus niveus and Smilax ferox.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Potential of Extracts of Selected Medicinal Plants from Nepal

Pant,

Joshi,

Aryal

2024

Tribhuvan University Journal

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Exploring antidiabetic & antibacterial potential of Ag/MgO-NCs mediated via Ficus auriculata: Experimental and computational analysis

Negi,

Tamta,

Pandey

et al. 2025

Inorganic Chemistry Communications

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Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans

Serrano-Díaz

Williams

Vega-Arreguín³

et al. 2023

Green Processing and Synthesis

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Candida albicans is the most predominant fungal species isolated from medical devices, including catheters, heart valves, and dental prostheses. In recent years, it has been demonstrated to be resistant to many antifungals; therefore, silver nanoparticles (AgNPs) have been proposed as an alternative. But only a handful of research is contributed to omic-based studies to study the various impacts of AgNPs on Candida species and other microorganisms. Thus, the study aims to biosynthesize AgNPs using Pelargonium-hortorum leaf and test its antifungal, cytotoxicity, and global gene expression on Candida through transcriptomic profiling. The leaf-assisted AgNPs resulted in spherical shapes with a particle size of 38 nm. The anticandidal effect demonstrated that the Minimum inhibitory concentration was 25 μg·mL−1. Later, the cytotoxicity assay reported a moderate impact on the human gingival fibroblast cells. Finally, the transcriptomic analysis demonstrated the differential gene expression of 3,871 upregulated and 3,902 downregulated genes. Thus, proving the anticandidal effect of AgNPs on Candida through RNA-seq experiments and the regulated genes is highly important to cell wall integrity, adherence, and virulence.

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Synthesis and evaluation of antibacterial, anti-fungal, anti-inflammatory properties of silver nanoparticles mediated via roots of Smilax aspera

Cited by 3 publications

References 13 publications

Phytochemical Screening and Antioxidant Potential of Extracts of Selected Medicinal Plants from Nepal

Phytochemical Screening and Antioxidant Potential of Extracts of Selected Medicinal Plants from Nepal

Exploring antidiabetic & antibacterial potential of Ag/MgO-NCs mediated via Ficus auriculata: Experimental and computational analysis

Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans

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