Synthesis and evaluation of antiinflammatory activity of substituted chalcone derivatives

Abstract

In an effort to develop potent antiinflammatory agents, a series of substituted chalcone derivatives was synthesized and evaluated for antiinflammatory activity through monitoring of their ability to inhibit xylene-induced ear edema in mice. Some of the tested compounds exhibited significant activity, and compounds 3f [(E)-1-(2,4-dihydroxyphenyl)-3-(4-dimethylamino)phenyl)prop-2-en-1-one] and 3h [(E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one] showed the highest antiinflammatory activity (62 and 68% inhibition, respectively, 2 h before administration), comparable with or even slightly more potent than the

"Ca@Al-BENTONITE: A NEW MATERIAL FOR CHALCONE PRODUCTION "

“…[1][2][3][4][5] They denoted remarkable biological advantages such as anticancer, anti-inflammatory, antioxidant, antimalarial, antitubercular and antimicrobial activities. [6][7][8][9][10][11] Generally, chalcones are produced by using base catalysts via Claisen-Schmidt Aldol condensation. [12][13][14] Indeed, due to the interesting application of chalcones, many novel synthetic methodologies have been utilized.…”

Vibrational spectra analysis, NBO, HOMO–LUMO, and nonlinear optical behavior studies on 3-(3,4-dimethoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one

“…Chalcones are abundant in edible plants [1], have relatively low redox potentials and have a greater probability of undergoing electron transfer reactions [2]. These compounds have attracted increasing attention due to numerous pharmacological applications [3][4][5][6]. These compounds exhibit good second harmonic generation (SHG) efficiency, excellent blue light transmittance [7,8], good crystallizability [9][10][11][12], better optical limiting behavior with nanosecond laser pulses at 532 nm wavelength [13], and ultrafast optical nonlinearities at 780 nm [14].…”

Synthesis of O-alkyl derivatives of dehydrozingerone analogues

“…They show good antifungal [1][2][3], antimicrobial [4][5][6], anticonvulsant [7], antioxidant [8][9][10], antiprotozoal [11], antitrichomonal [12] antimalarial [13][14][15], antiinflammatory [16][17][18], trypsin inhibitors [19] and anti-cancer activity [20][21][22][23]. At this kind of molecules is important to identify the fragment of their structure responsible for previously described activities.…”