Synthesis and evaluation of cyclic nitrone derivatives as potential anti-cancer agents

Synthesis of substituted 5‐aryl‐2,3‐dihydropyrazine 1,4‐dioxides based on condensation of N,N′‐(2,3‐dimethylbutane‐2,3‐diyl)bis(hydroxylamine) with various arylglyoxals

“…Among diverse types of compounds with a nitrone moiety, cyclic derivatives are an important subclass possessing extensive synthetic utility and interesting biological activity. For example, cyclic nitrones containing an indole core exert antiproliferative action against various cancer cell lines [2]. Besides that, another broad application of these compounds is associated with the ability of nitrones to act as a free‐radical scavenger and to capture reactive oxygen species in human cells.…”