Synthesis and evaluation of D-glucosamine-selective fluorescent sensors

A highly selective fluorescent sensor for glucosamine

“…17,18 Typically, sensors which bind ammonium ions use crown ethers as a recognition group. However, the high structural similarity of these biological amines, in addition to the complexity of cellular media, makes this endeavour difficult.…”

Saccharide-Selective Boronic Acid Based Photoinduced Electron Transfer (PET) Fluorescent Sensors

“…The fluorescence titrations of compound 17 (7.5 × 10 -7 mol dm -3 , λ ex = 342 nm) with different saccharides were carried out in a pH 8.21 aqueous methanolic buffer solution [52.1 wt % methanol (KCl, 10.00 × 10 -3 mol dm -3 ; KH 2 PO 4 , 2.752 × 10 -3 mol dm -3 ; Na 2 HPO 4 , 2.757 × 10 -3 mol dm -3 )]. The K obs with coefficient of determination (r 2 ) was calculated by the fitting of emission intensity versus saccharide concentration using custom-written non-linear (Levenberg-Marquardt algorithm) curve fitting [88]. The errors reported are the standard errors obtained from the best fit.…”

Molecular Logic Gates and Luminescent Sensors Based on Photoinduced Electron Transfer

“…For instance, sugar binding to aminomethylphenylboronic acid to produce boronate ester leads to a stronger B-N bond which stops the PET process. Then 34 [85,86] with the two receptors at the appropriate distance of separation could target glucosamine. In this case, the pH value needs to be chosen so that glucosamine is protonated but not the nitrogen centre in the azacrown ether.…”