“…In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F‐radiolabelled tetrazines for use in pretargeted imaging of amyloid‐beta. First 6‐[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F] 51‐54 as seen in Figure 9.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…Each tetrazine was able to cross with BBB with peak SUVs between 1.5 and 2 decreasing to 0.29–0.59 at 60 min p.i. for the methyl‐tetrazines, [ 18 F] 52 and [ 18 F] 54 54 . Further evaluation is currently underway in order to assess how effective these tetrazines are for use in pretargeted imaging.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…Structures of the four tetrazines [ 18 F] 51–54 synthesised by Schlein et al 54 for use in pretargeted imaging of amyloid beta.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…This highlighted the fine balance between reactivity and stability and reiterates the importance of the careful consideration of the properties of tetrazines and TCOs when selecting the reactive handle conjugated to the targeting molecule. 53 In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F-radiolabelled tetrazines for use in pretargeted imaging of amyloid-beta. First 6-[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F]51-54 as seen in Figure 9.…”
Section: Brain Penetrant Tetrazinesmentioning
confidence: 99%
“…for the methyl-tetrazines, [ 18 F]52 and [ 18 F]54. 54 Further evaluation is currently underway in order to assess how effective these tetrazines are for use in pretargeted imaging.…”
How to cite this article: Zientek SH, Thompson S, Sephton SM, Aigbirhio FI. The inverse electron demand Diels-Alder cycloaddition with carbon-11 and fluorine-18: A gateway to pretargeted imaging across the blood-brain barrier.
“…In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F‐radiolabelled tetrazines for use in pretargeted imaging of amyloid‐beta. First 6‐[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F] 51‐54 as seen in Figure 9.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…Each tetrazine was able to cross with BBB with peak SUVs between 1.5 and 2 decreasing to 0.29–0.59 at 60 min p.i. for the methyl‐tetrazines, [ 18 F] 52 and [ 18 F] 54 54 . Further evaluation is currently underway in order to assess how effective these tetrazines are for use in pretargeted imaging.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…Structures of the four tetrazines [ 18 F] 51–54 synthesised by Schlein et al 54 for use in pretargeted imaging of amyloid beta.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…This highlighted the fine balance between reactivity and stability and reiterates the importance of the careful consideration of the properties of tetrazines and TCOs when selecting the reactive handle conjugated to the targeting molecule. 53 In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F-radiolabelled tetrazines for use in pretargeted imaging of amyloid-beta. First 6-[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F]51-54 as seen in Figure 9.…”
Section: Brain Penetrant Tetrazinesmentioning
confidence: 99%
“…for the methyl-tetrazines, [ 18 F]52 and [ 18 F]54. 54 Further evaluation is currently underway in order to assess how effective these tetrazines are for use in pretargeted imaging.…”
How to cite this article: Zientek SH, Thompson S, Sephton SM, Aigbirhio FI. The inverse electron demand Diels-Alder cycloaddition with carbon-11 and fluorine-18: A gateway to pretargeted imaging across the blood-brain barrier.
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