2022
DOI: 10.1016/s0969-8051(22)00232-3
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for amyloid PET-imaging

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“…In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F‐radiolabelled tetrazines for use in pretargeted imaging of amyloid‐beta. First 6‐[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F] 51‐54 as seen in Figure 9.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
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“…In a conference abstract, Schlein et al 54 reported the synthesis of four 18 F‐radiolabelled tetrazines for use in pretargeted imaging of amyloid‐beta. First 6‐[ 18 F]fluoronicotinic acid tetrafluorophenyl ester was synthesised on a solid support and then coupled to amine or aminooxy bearing tetrazines to give [ 18 F] 51‐54 as seen in Figure 9.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
“…Each tetrazine was able to cross with BBB with peak SUVs between 1.5 and 2 decreasing to 0.29–0.59 at 60 min p.i. for the methyl‐tetrazines, [ 18 F] 52 and [ 18 F] 54 54 . Further evaluation is currently underway in order to assess how effective these tetrazines are for use in pretargeted imaging.…”
Section: Brain Penetrant Tcosmentioning
confidence: 99%
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