2013
DOI: 10.1016/j.ejmech.2013.09.055
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Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors

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Cited by 27 publications
(8 citation statements)
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“…Synthetic procedures are multistep [1718] though sometimes they can be performed as one-pot syntheses [19]. Several catalytic approaches have been described in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…Synthetic procedures are multistep [1718] though sometimes they can be performed as one-pot syntheses [19]. Several catalytic approaches have been described in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…To determine whether the inhibition of HCV replication by vitisin B could reduce HCV protein production, we first plated Huh7.5 cells and incubated them with increasing concentrations of vitisin B for 2 h, followed by inoculation with a JFH1 virus expressing an NS5A‐GFP fusion protein (Huh7.5‐JFH1‐NS5A‐GFP cells) (GT2a) (Hwang et al ., ). At 72 h post infection, the HCV infection rates were determined by fully automated confocal microscopic analysis.…”
Section: Resultsmentioning
confidence: 97%
“…Rluc-J6/JFH1 (FL-J6/JFH-50C19Rluc2AUbi) is a HCV genotype 2a infectious clone described previously [ 16 , 31 ]. JFH-1-5A-GFP is an infectious genotype 2a HCV genome, which expresses the NS5A-GFP fusion protein [ 32 ]. Bart79I is a high-efficiency bicistronic subgenomic replicon of HCV obtained from the HCV genotype 1b Con1 sequence described previously [ 30 ].…”
Section: Methodsmentioning
confidence: 99%