Synthesis and Evaluation of Hydroxycamptothecin-encapsulated Chitosan Nanospheres for the Treatment of Liver Cancer

Han, Jing; Hou, Zhenqing; Wang, Y. G.; Guo, Xijing

doi:10.7785/tcrt.2012.500404

Cited by 14 publications

(5 citation statements)

References 16 publications

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“…195,196 Studies have shown that chitosan NPs prolong the duration of HCPT administration, improve oral bioavailability, and improve antitumor effects while reducing side effects. [197][198][199] Positively charged chitosan NPs exhibited slow-release behavior, ensuring higher intracellular drug concentrations and more significant cytotoxicity. 200 FA-modified chitosan nanoneedles (Figure 5) and micelles exhibit significantly enhanced cellular uptake, higher cytotoxicity against folate-receptor-positive tumor cells.…”

Section: Chitosan-based Npsmentioning

confidence: 99%

“…In vitro and In vivo [183] Electrospun fibers-based NPs Chemotherapy In vivo [185,192] Chemotherapy In vitro and In vivo [186][187][188]190] Polysaccharide-based (Chitosan) NPs Chemotherapy In vitro [197,199] Chemotherapy In vitro and In vivo [198,[201][202][203] Chemotherapycombined with Gas Therapy In vitro and In vivo [ In vivo [284] Chemotherapy In vitro and In vivo [281,282,285,286] Chemotherapy combined with PDT In vitro and In vivo [278,279] https://doi.org/10.2147/IJN.S377149…”

Section: Chemotherapymentioning

confidence: 99%

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Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.

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Section: Chitosan-based Npsmentioning

confidence: 99%

Section: Chemotherapymentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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“…Hydroxycamptothecin (HCPT) loaded chitosan nanospheres (average size of about 330 nm) were prepared using the membrane emulsification technique [60]. HCPT is an alkaloid isolated from the Camptotheca acuminate in China.…”

Section: Drug Loaded Chitosan Nanoparticlesmentioning

confidence: 99%

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

et al. 2020

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Chitosan nanoparticles are well-known delivery systems widely used as polymeric carriers in the field of nanomedicine. Chitosan is a carbohydrate of natural origin: it is a biodegradable, biocompatible, mucoadhesive, polycationic polymer and it is endowed with penetration enhancer properties. Furthermore, it can be easily derivatized. Hepatocellular carcinoma (HCC) represents a remarkable health problem because current therapies, that include surgery, liver transplantation, trans-arterial embolization, chemoembolization and chemotherapy, present significant limitations due to the high risk of recurrence, to a lack of drug selectivity and to other serious side effects. Therefore, there is the need for new therapeutic strategies and for improving the liver-targeting to HCC. Nanomedicine consists in the use of nanoscale carriers as delivery systems to target and deliver drugs and/or diagnostic agents to specific organs or tissues. Chitosan and its derivatives can be successfully used in the preparation of nanoparticles that, for their peculiar surface-properties, can specifically interact with liver tumor, by passive and active targeting. This review concerns the use of chitosan nanoparticles for the therapy and theranostics of HCC and liver-targeting.

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“…These NPs induced receptor-mediated endocytosis and also have prolonged blood circulation time, enhanced liver accumulation and reduced side effects, such as cardiotoxicity associated with doxorubicin [68]. In a related study, Han and colleagues [69] demonstrated that hydroxycamptothecin, a camptothecin derivative, could also reduce tumor weights and growth rates of liver cancer in vivo, when encapsulated in chitosan (HCS) NSs [69].…”

Section: Nk911mentioning

confidence: 97%

Nanoformulations for Therapy of Pancreatic and Liver Cancers

Souza

Ranjan

Towner

2015

Nanomedicine (Lond.)

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Pancreatic and liver cancers often have poor prognoses. Clinically, pancreatic and liver cancer requires early diagnosis, and surgery is often associated with tumor recurrence. Currently, chemotherapies are limited in their ability to accurately target the tumors, and are associated with significant toxicity in patients. Targeting of chemotherapy can be improved by encapsulation in nanocarriers. A variety of preclinical studies indicate relatively superior therapeutic outcomes compared with drug alone therapy. Targeted nanoparticle imaging agents may also additionally facilitate better diagnosis and improve patient outcomes. This review discusses the nanoformulations that are under investigation (mainly preclinical studies, but also with some current clinical trial examples) against pancreatic and liver cancers, understands the challenges and provides future perspectives.

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Synthesis and Evaluation of Hydroxycamptothecin-encapsulated Chitosan Nanospheres for the Treatment of Liver Cancer

Cited by 14 publications

References 16 publications

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

Nanoformulations for Therapy of Pancreatic and Liver Cancers

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