Synthesis and evaluation of mono- and multi-hydroxyl low toxicity pH-sensitive cationic lipids for drug delivery

Lipid-Based Drug Delivery Systems in Regenerative Medicine

“…These are particularly suitable for poorly water-soluble drugs [ 54 ]. Lipids consist of both hydrophilic and hydrophobic portions and can self-assemble to form a variety of structures [ 55 ]. Cationic lipids are suitable for the delivery of drugs and genes [ 56 ].…”

“…Trehalose is a natural non-reducing disaccharide that cannot easily penetrate the skin. Emanuele [ 55 ] encapsulated trehalose in liposomes and found that, compared to commonly used photoprotective compounds such as L-carnosine, L-(+)-lysergic acid, and L-ascorbic acid, trehalose-loaded liposomes significantly reduced the levels of CPD and 8OHdG along with protein carbonylation in cells, indicating that the liposomes show promise for treating skin damage caused by UVB radiation.…”

Lipophilic Polyamines as Promising Components of Liposomal Gene Delivery Systems

“…The CA structure significantly affects the efficiency of NA delivery to eukaryotic cells. In recent years, many monocationic amphiphiles have been obtained [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ] that form liposomes for NA delivery. In this review, we will consider polycationic amphiphiles, which, compared to monocationic analogs, enable the more efficient transport of NAs into cells due to the formation of a system of distributed charges in the polyamine matrix and their ability to facilitate NA release from endosomes.…”

Amphiphilic ionic liquids as sustainable components to formulate promising vesicles to be used in nanomedicine

“…Since the discovery of this self-assembly phenomenon in the 1960s, lipid-based self-assembled nanostructures have been widely studied and applied in drug delivery systems. [2] Thus, a variety of vesicular systems can be designed, either to deliver hydrophilic molecules encapsulated in the water core or hydrophobic drugs integrated to the lipid bilayer. It is worthy to mention here that, upon solubilization in water the phospholipid bilayer first exists as a lamella (a flat plate-like structure) before getting converted into spheres.…”

“…[24] Particularly, some unilamellar vesicles have been synthesized with catanionic surfactants and showed higher stability when compared to liposomes. [2,25] When the catanionic surfactant, BHD-AOT (Scheme 1) was synthesized in the lab for the first time it was found that met all properties of an IL. The catanionic surfactant BHD-AOT, prepared from an equimolar mixture of the anionic surfactant [26] sodium 1, and the cationic surfactant benzyl-n-hexadecyldimethylammonium chloride (BHDC), for instance, showed IL-like properties.…”