Synthesis and evaluation of octenyl succinate anhydride derivative of fenugreek gum as extended release polymer

Sav, Ajay Kumar; Fule, Ritesh; Ali, Meer Tarique; Amin, Purnima D.

doi:10.1007/s40005-013-0088-x

Cited by 14 publications

(3 citation statements)

References 23 publications

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“…3 b). The results obtained were found to be in concordance with the findings of Sav et al , 2013 [ 33 ].…”

Section: Resultssupporting

confidence: 92%

Leucaena leucocephala succinate based polyelectrolyte complexes for colon delivery of synbiotic in management of inflammatory bowel disease

Kaur,

Kumar,

Kurl

et al. 2024

Heliyon

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“…3 b). The results obtained were found to be in concordance with the findings of Sav et al , 2013 [ 33 ].…”

Section: Resultssupporting

confidence: 92%

Leucaena leucocephala succinate based polyelectrolyte complexes for colon delivery of synbiotic in management of inflammatory bowel disease

Kaur,

Kumar,

Kurl

et al. 2024

Heliyon

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“…Similar findings have been asserted by different authors, such as Sara et al [29] for hydrophobically modified xanthan gum, and also by Chen et al [39], who reported that the hydroxybutylation reaction took place in the amorphous area and had very little effect on the crystallinity of waxy corn starch. However, Sav et al [40] affirmed that hydrophobic modification slightly influenced the crystalline nature of the octenyl succinate anhydride derivative of fenugreek gum.…”

Section: X-ray Diffraction Analysis (Xrd)mentioning

confidence: 99%

Development of New Alkylated Carrageenan Derivatives: Physicochemical, Rheological, and Emulsification Properties Assessment

et al. 2023

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In this research, amphiphilic derivatives of kappa carrageenan (KC) were synthesized by hydrophobic modification with an alkyl halide (1-Octyl chloride). Three hydrophobic polymers with different degrees of substitution (DS) were obtained by the Williamson etherification reaction in an alkaline medium. The effect of the molar ratio (R = reagent/polymer) on the DS was investigated at different ratios (1, 2, and 3). The KC derivatives (KCRs) were characterized by different techniques such as FT-IR, 1H-NMR, X-ray Diffraction, Scanning electron microscopy, and a rheological assessment. The FT-IR and 1HNMR analyses confirmed the binding of the hydrophobic groups onto the KC molecule. The degrees of substitution calculated by 1H-NMR demonstrated that the derivative KCR3 (0.68) presented a higher degree of substitution compared to KCR1(0.45) and KCR2 (0.53). The XRD and SEM analyses revealed that the alkaline etherification conditions did not alter the morphological and crystallographic properties, as well as the rheological behavior of the obtained derivatives. The amphiphilic character of the KCRs was investigated using a conductivity method which revealed that the molecular aggregation occurred above the critical aggregation concentration (CAC). Decreasing CAC values of 0.15% (KCR1), 0.11% (KCR2) and 0.08% (KCR3)with the degree of substitution (DS) were found. Furthermore, KCR’s derivatives greatly improved the stability of oil/water emulsions as the droplet size decreased with increasing DS. The derivative (KCR3) with higher DS, showed a greater amphiphilic character, and improved emulsifying power.

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“…It is cultivated in Northern Africa, the Mediterranean, Western Asia, Northern India, and in Canada [6,7]. Application of fenugreek seed gum (FSG) has been reported as oral drug release retardant [7][8][9], binder [10][11][12], mucoadhesive [13,14], emulsifiers [15][16][17], suspending agent [18], gelling agent [19], and formulation of nanoparticles [20,21].…”

Section: Introductionmentioning

confidence: 99%

Development of Natural and Modified Gum Based Sustained-Release Film-Coated Tablets Containing Poorly Water-Soluble Drug

Shukla

Bishnoi

Kumar

et al. 2019

Asian J Pharm Clin Res

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Objective: The objective of this work was to the development of natural and modified gum based sustained-release film-coated tablets containing poorly water-soluble drug. Methods: Tamarind seed gum (TSG), fenugreek seed gum (FSG), sodium trimetaphosphate, hydroxypropyl methylcellulose (HPMC), sodium alginate (SA), and nifedipine (NFD) were used. The core tablets of nifedipine were prepared and evaluated for weight, diameters, thickness, hardness, and disintegration time. The core tablets were coated using 2% w/v solution of TSG, MTSG, FSG, and MFSG. The in vitro release rate of drug from these coated tablets was compared with the release rate of drug from the tablets coated with 2% w/v of HPMC. Results: The tablets coated with natural and modified TSG sustained the release of the drug up to 11 h and 14 h, respectively, and natural and modified FSG sustained release the drug up to 9 h and 11 h, respectively. The tablets coated with HPMC sustained released the drug up to 15 h. The drug release profile of tablets coated with modified TSG was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile, it is concluded that unmodified and modified TSG can be used as release rate-controlling membrane.

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Synthesis and evaluation of octenyl succinate anhydride derivative of fenugreek gum as extended release polymer

Cited by 14 publications

References 23 publications

Leucaena leucocephala succinate based polyelectrolyte complexes for colon delivery of synbiotic in management of inflammatory bowel disease

Leucaena leucocephala succinate based polyelectrolyte complexes for colon delivery of synbiotic in management of inflammatory bowel disease

Development of New Alkylated Carrageenan Derivatives: Physicochemical, Rheological, and Emulsification Properties Assessment

Development of Natural and Modified Gum Based Sustained-Release Film-Coated Tablets Containing Poorly Water-Soluble Drug

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