2016
DOI: 10.1016/j.carbpol.2016.03.014
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Synthesis and evaluation of oxidation-responsive alginate-deferoxamine conjugates with increased stability and low toxicity

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Cited by 18 publications
(15 citation statements)
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“…inhibits the adsorption of proteins such as enzymes, thereby reducing the degradation of 8-arm-PEG conjugated DFO [27]. In addition, the remaining DFO content of the 8-arm-PEG40k-DFO was always higher than the content of the 8-arm-PEG20k-DFO after 5 hours of incubation, which indicated that the higher molecular weight conjugate had more tendencies to slow the degradation of DFO.…”
Section: In Vitro Metabolism Testmentioning
confidence: 99%
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“…inhibits the adsorption of proteins such as enzymes, thereby reducing the degradation of 8-arm-PEG conjugated DFO [27]. In addition, the remaining DFO content of the 8-arm-PEG40k-DFO was always higher than the content of the 8-arm-PEG20k-DFO after 5 hours of incubation, which indicated that the higher molecular weight conjugate had more tendencies to slow the degradation of DFO.…”
Section: In Vitro Metabolism Testmentioning
confidence: 99%
“…The metabolism studies were carried out as per the method described in a previous report [27]. First, the blood was centrifuged at 10,000 rpm for 5 min at 4 • C to separate the plasma.…”
Section: In Vitro Metabolism Studiesmentioning
confidence: 99%
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“…Actually, some studies had proven that conjugation of DFO into polymer carriers, such as hydroxyethyl starch, dextran, dialdehyde cellulose, nanoparticles, and polyethylene glycol copolymer, significantly prolonged the half-life comparing to the free of DFO (Tian et al, 2016a). To better of our knowledge, there is no report on systematic study of the DFO-based bloodconjugates interactions.…”
Section: Introductionmentioning
confidence: 99%