Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents

Abstract

Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-carboxylate (5a-b).The structures of these compounds were established on the basis of their spectral (IR, 1 H-NMR) data.These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.

Design, Synthesis, Characterization and Preliminary Anticancer Study for Methotrexate Silibinin Conjugates

“…A suspension of cystine (41.6mmole,10g) in (150 ml)of absolute methanol,was cooled to -15 ᵒ C then thionyl chloride(99.8 mmole,7.4 ml) was added drop wise ,(the temperature should be keep below -10 ᵒ C) and the reaction mixture was left at 40 ᵒ C for 1hr,then reflux for 4 hr and left at room temperture over night,the excess solvent was evaporated to dryness under vacuum;recrystallize the product from methanol-diethyl ether and collected as HCl salt (23) .…”