Synthesis and evaluation of platinum complexes with potential antitumor activity

Abstract

A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.Uniterms:. /Cytotoxic activity. Platinum complexes/ Ehrlich solid tumor activity.

Trypan Blue Exclusion Assay Verifies in Vitro Cytotoxicity of New Cis-Platinum (II) Complex in Human Cells

“…Cisplatin, cis-DDP (Cis-diamminedichloroplatinum II) is one of the most successful compounds for treating wide varieties of cancers (3). Even though cisplatin is a valuable antitumor drug, it has numerous drawbacks side effects, such as nephrotoxicity, ototoxicity, neurotoxicity, myelotoxicity, peripheral neuropathy and hematological toxicity (4).…”