Synthesis and evaluation of radioiodinated terminal para-iodophenyl-substituted .alpha.- and .beta.-methyl-branched fatty acids

Goodman, M. M.; Kirsch, G.; Knapp, F.F.

doi:10.1021/jm00369a027

Cited by 136 publications

(51 citation statements)

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“…Iodine 123-labeled BMIPP (I-123 BMIPP) is a modified fatty acid in which methyl branching has been introduced into the β -position to inhibit beta-oxidation in human myocardium, and has suitable characteristics for myocardial single-photon emission computed tomography (SPECT) because of its high uptake and longer retention in the myocardium [7,9].…”

Section: -(P-iodophenyl)-9-(rs)-methylpentadecanoic Acid and 15-(pmentioning

confidence: 99%

A compartment model analysis for investigation of myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy

Okizaki¹,

Shuke²,

Sato³

et al. 2007

Nuclear Medicine Communications

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Objective: The purpose of this study was to investigate the myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy (HCM) from dynamic SPECT through a compartment model analysis. Methods: Twenty-four normal controls, 7 patients with left ventricular hypertrophy (LVH) due to essential hypertension (eHT), and 30 patients with HCM were studied. I-123 BMIPP and Tc-99m tetrofosmin SPECT were performed. All the myocardium was divided into 13 segments, and totally 390 segments of HCM were categorized into early, moderately and severely advanced HCM segments, based on these SPECT imaging.By using the myocardial and blood pool time-activity curves, BMIPP pharmacokinetics was analyzed through a 2-compartment model. We defined k1 and k2 as influx and outflux rate constants between blood and myocardial reversible component, k3 as specific uptake rate constant between myocardial reversible and irreversible compartments. Results: The averages of k3 in HCM were higher than in normal. In contrast, the averages of k1/k2 in HCM were lower than in normal, and gradually decreased with progression of HCM. There are no significant differences in these indexes between normal controls and patients with LVH due to eHT.Conclusion: k3 might be a sensitive predictor for early detection of HCM, and k1/k2 could be a useful index to evaluate its progression. A mathematical compartment model analysis with BMIPP SPECT study might be useful not only for identification of HCM in very early stage, but also for evaluation of the progression of HCM.

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Section: -(P-iodophenyl)-9-(rs)-methylpentadecanoic Acid and 15-(pmentioning

confidence: 99%

A compartment model analysis for investigation of myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy

Okizaki¹,

Shuke²,

Sato³

et al. 2007

Nuclear Medicine Communications

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“…Especially fluorine and (to a lesser extent) chlorine will exert their influence via such a mechanism. This effect becomes less pronounced for • Iodinated linoleic and linolenic acid gave results, indistinguishable from iodinated oleic acid' 31 . t LV: the uptake in the left ventricle (LV) is given.…”

Section: Labelling In the 2-positionmentioning

confidence: 92%

Myocardial Uptake of Radioactively Labelled Free Fatty Acids

Westera

Visser

1985

European Heart Journal

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KEY WORDS: Myocardial uptake, free fatty acids. Structural variations in the carbon chain of free fatty acids influence the uptake of free fatty acids in the myocardium. To enable the use of free fatty acids in nuclear cardiology, various methods of introducing gammaemitting isotopes have been evaluated.The uptake of various free fatty acids is described and structure-activity relationships deduced.

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“…Iodinated fatty acids are particularly useful for imaging because they are taken up by myocardium as normal, but are metabolised with relatively long retention in the myocardium [32]. Fatty acid is the normal substrate for energy production in the myocardium.…”

Section: Radiopharmaceuticalsmentioning

confidence: 99%

Myocardial perfusion scintigraphy: past, present and future

Notghi

Low²

2011

BJR

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ABSTRACT. During the last two decades, radionuclide myocardial perfusion scintigraphy (MPS) has become established as the main functional cardiac imaging technique for the assessment of ischaemic heart disease (IHD). Despite a growing number of alternative functional imaging techniques, MPS still remains the most widely used technique, with a wealth of literature supporting its usefulness in assessing IHD and predicting prognosis. The technique itself has evolved, making it more reliable and robust, with additional ventricular functional information that further defines the prognosis in these patients. With the advent of hybrid single photon emission with CT and positron emission tomography with CT cameras together with the development of new camera technology that enables faster images with less radiation and better resolution, MPS will remain an essential part of IHD investigation. There are new promising radiopharmacological developments and applications such as radiolabelled fatty acids and metaiodobenzylguanidine. These will widen the scope of nuclear medicine imaging to include patients with cardiac failure and acute chest pain presenting to accident and emergency departments. Nuclear medicine cardiac investigations will continue to have an essential role in the diagnosis, stratification and prognosis of patients with cardiac disease, complementing the new developing cardiac modalities such as CT coronary angiography and MRI.

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Synthesis and evaluation of radioiodinated terminal para-iodophenyl-substituted .alpha.- and .beta.-methyl-branched fatty acids

Cited by 136 publications

References 0 publications

A compartment model analysis for investigation of myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy

A compartment model analysis for investigation of myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy

Myocardial Uptake of Radioactively Labelled Free Fatty Acids

Myocardial perfusion scintigraphy: past, present and future

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