Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents

One-pot solvent-free synthesis of pyranonaphthoquinone-fused spirooxindoles catalyzed by SBA-IL

“…In this respect, indole nuclei represent an important class of bioactive heterocyclic compounds in organic and medicinal chemistry [14]. In addition, it has been reported that the biological activity will be highly improved in C-3 spiroindoline derivatives [15]. The resulting spirooxindoles are found in a variety of natural products and bioactive molecules (Figure 1).…”

A Clean Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives

“…[4][5][6] The spirooxindole system is the core structure of many pharmacological agents and natural alkaloids. [7][8][9][10] For example, spirotryprostatins A and B, two natural alkaloids isolated from the fermentation broth of Aspergillus fumigatus, have been identified as two novel inhibitors of microtubule assembly, 8) and pteropodine and isopteropodine have been shown to modulate the function of muscarinic serotonin receptors.…”

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

“…Furthermore, it has been reported that sharing of the indole 3-carbon atom in the formation of spiroindoline derivatives greatly enhances biological activity against some Gram-positive bacteria (Bacillus subtilis and B. megatherium, Gram negative bacteria (Escherichia coli) and fungi (Aspergillus niger and A. oryzae) [9][10][11] . The spiro-oxindole system is the core structure of many pharmacological agents and natural alkaloids such as spiroindole-thiazolidinones which show good activity against the pathogens Rhizoctonia solani, Fusarium oxysporum and Collectotrichum capsici.…”